Sim Eun Hee, Lee Hye Won, Choi Hyun Ju, Jeong Dong Wook, Son Seok Man, Kang Yang Ho
Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.
Diabetes Metab J. 2016 Feb;40(1):62-9. doi: 10.4093/dmj.2016.40.1.62.
Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of diabetes in Korean adults.
We analyzed data from 1,559 Korean adults (937 men and 622 women) with available serum cystatin C and HbA1c values.
The serum cystatin C levels in subjects with prediabetes and diabetes were significantly increased (0.91±0.14 mg/L in prediabetes and 0.91±0.17 mg/L in diabetes vs. 0.88±0.13 mg/L in patients with normal glucose levels, P=0.001). At increasing cystatin C levels, the prevalence of subjects with prediabetes (30.2% vs. 14.6%, P<0.001) and those with diabetes (10.6% vs. 8.0%, P<0.001) significantly increased in the group with the highest cystatin C levels. The group with the highest cystatin C levels had a significantly increased odds ratio (OR) for the presence of diabetic conditions compared to the group with the lowest values in total subjects (OR, 2.35; 95% confidence interval [CI], 1.54 to 3.58; P<0.001) and in women (OR, 4.13; 95% CI, 1.97 to 8.65; P<0.001), though there was no significant increase after adjusting for multiple variables.
Higher levels of serum cystatin C are associated with an increased prevalence of diabetic conditions in Korean adults. Our findings may extend the positive association of cystatin C with diabetes incidence to an Asian population.
已知胱抑素C不仅与早期肾功能损害有关，还与糖尿病状态（糖尿病前期加糖尿病）的发生率有关。然而，尚不清楚胱抑素C水平是否与亚洲人群中糖尿病状态的患病率相关。我们在韩国成年人中使用糖化血红蛋白（HbA1c）水平作为糖尿病的定义来评估这种关联。
我们分析了1559名韩国成年人（937名男性和622名女性）的血清胱抑素C和HbA1c值数据。
糖尿病前期和糖尿病患者的血清胱抑素C水平显著升高（糖尿病前期为0.91±0.14mg/L，糖尿病为0.91±0.17mg/L，而血糖正常患者为0.88±0.13mg/L，P=0.001）。随着胱抑素C水平升高，胱抑素C水平最高组中糖尿病前期患者（30.2%对14.6%，P<0.001）和糖尿病患者（10.6%对8.0%，P<0.001）的患病率显著增加。与胱抑素C水平最低组相比，胱抑素C水平最高组在所有受试者中糖尿病状态的比值比（OR）显著升高（OR，2.35；95%置信区间[CI]，1.
