Bai Qi, Liu Li, Long Qilai, Xia Yu, Wang Jiajun, Xu Jiejie, Guo Jianming
Department of Urology, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University Shanghai 200032, China.
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11005-14. eCollection 2015.
MUC18 is correlated with tumor progression and metastasis in types of malignancy. But the role of MUC18 in clear cell renal cell carcinoma remains unclear. In this study, we aimed to investigate the expression of MUC18 and its correlation with clinical outcomes in clear cell renal cell carcinoma.
Immunohistochemical staining was performed in samples from 288 patients with clear cell renal cell carcinoma. We used Kaplan-Meier method and Cox proportional hazard models to value the association between MUC18 expression and clinical outcome. Nomogram was constructed to predict overall survival at 5 and 8 years after nephrectomy.
MUC18 expression was significantly decreased in tumor compared to non-tumor tissue (P<0.001). Lower MUC18 expression in tumor predicted a shorter survival time (P=0.007). By multivariate cox analysis, MUC18 was defined as an independent prognostic factor (P=0.006). The nomogram performed better in predicting 5- and 8-year overall survival than the TNM stage alone in clear cell renal cell carcinoma.
MUC18 is an independent prognostic factor for clear cell renal cell carcinoma and could be incorporated with the other parameters to predict 5- and 8-year overall survival for clear cell renal cell carcinoma patients.
MUC18与多种恶性肿瘤的肿瘤进展和转移相关。但MUC18在透明细胞肾细胞癌中的作用仍不清楚。在本研究中，我们旨在探讨MUC18在透明细胞肾细胞癌中的表达及其与临床结局的相关性。
对288例透明细胞肾细胞癌患者的样本进行免疫组织化学染色。我们使用Kaplan-Meier法和Cox比例风险模型来评估MUC18表达与临床结局之间的关联。构建列线图以预测肾切除术后5年和8年的总生存率。
与非肿瘤组织相比，肿瘤组织中MUC18表达显著降低（P<0.001）。肿瘤组织中MUC18表达较低预示着生存时间较短（P=0.007）。通过多因素Cox分析，MUC18被确定为独立的预后因素（P=0.006）。在预测透明细胞肾细胞癌的5年和8年总生存率方面，列线图比单独的TNM分期表现更好。
MUC18是透明细胞肾细胞癌的独立预后因素，可与其他参数结合用于预测透明细胞肾细胞癌患者的5年和8年总生存率。
