缺氧、炎症与转移疾病中的肿瘤微环境。
Hypoxia, inflammation, and the tumor microenvironment in metastatic disease.
机构信息
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
出版信息
Cancer Metastasis Rev. 2010 Jun;29(2):285-93. doi: 10.1007/s10555-010-9224-5.
Abstract
Metastasis, the leading cause of cancer deaths, is an intricate process involving many important tumor and stromal proteins that have yet to be fully defined. This review discusses critical components necessary for the metastatic cascade, including hypoxia, inflammation, and the tumor microenvironment. More specifically, this review focuses on tumor cell and stroma interactions, which allow cell detachment from a primary tumor, intravasation to the blood stream, and extravasation at a distant site where cells can seed and tumor metastases can form. Central players involved in this process and discussed in this review include integrins, matrix metalloproteinases, and soluble growth factors/matrix proteins, including the connective tissue growth factor and lysyl oxidase.
摘要
转移是癌症死亡的主要原因，是一个涉及许多尚未完全定义的重要肿瘤和基质蛋白的复杂过程。这篇综述讨论了转移级联反应所必需的关键组成部分，包括缺氧、炎症和肿瘤微环境。更具体地说，这篇综述侧重于肿瘤细胞和基质的相互作用，这些相互作用使细胞从原发性肿瘤脱离、浸润到血液中，并在远处的部位逸出，在那里细胞可以播种，肿瘤转移可以形成。在这个过程中涉及的核心参与者，并在本综述中讨论了包括整合素、基质金属蛋白酶和可溶性生长因子/基质蛋白，包括结缔组织生长因子和赖氨酰氧化酶。
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