Williams Edith M, Bruner Larisa, Penfield Megan, Kamen Diane, Oates James C
Institute for Partnerships to Eliminate Health Disparities, University of South Carolina; Columbia, SC, USA.
Office of Public Health Practice, University of South Carolina; Columbia, SC, USA.
Rheumatology (Sunnyvale). 2014;2014(Suppl 4). doi: 10.4172/2161-1149.S4-005. Epub 2014 Nov 7.
While increased psychological distress in SLE has been clinically and empirically reported, the relationship between emotional distress, treatment adherence, and disease activity are complex and even more unclear in African American lupus patients. In an effort to elucidate this phenomenon in these patients, this exploratory study aimed to investigate relationships between stress, depression, and various health behaviors in this group.
Thirty patients invited to participate in this study were African American systemic lupus erythematosus (SLE) patients attending rheumatology clinics at the Medical University of South Carolina (MUSC). This study was part of a larger interventional pilot study, the Balancing Lupus Experiences with Stress Strategies (BLESS) study, that included a comprehensive battery of psychosocial, quality of life, and behavior change measures.
When looking at the association between anxiety/stress and functionality, levels of reported stress had strong effects upon functionality, especially between health distress and functionality. When looking at the association between depressive symptoms and functionality, depressive symptoms had moderate effects upon social/role limitations and nights spent in the hospital.
Not only did the larger pilot project demonstrate significant reductions in stress and depression as a result of workshop participation; this nested study also showed that those improvements were positively associated with improved health behaviors. These results could have implications for developing interventions to improve disease experience and quality of life in SLE patients with stress and depression.
虽然临床上和经验上都报告了系统性红斑狼疮（SLE）患者心理困扰增加的情况，但情绪困扰、治疗依从性和疾病活动之间的关系很复杂，在非裔美国狼疮患者中更不明确。为了阐明这些患者的这一现象，这项探索性研究旨在调查该群体中压力、抑郁和各种健康行为之间的关系。
受邀参加本研究的30名患者是非裔美国系统性红斑狼疮（SLE）患者，他们在南卡罗来纳医科大学（MUSC）的风湿病诊所就诊。本研究是一项更大的干预性试点研究“用压力策略平衡狼疮经历”（BLESS）研究的一部分，该研究包括一系列全面的心理社会、生活质量和行为改变测量。
在研究焦虑/压力与功能之间的关联时，报告的压力水平对功能有很大影响，尤其是在健康困扰和功能之间。在研究抑郁症状与功能之间的关联时，抑郁症状对社会/角色限制和住院天数有中等影响。
不仅更大规模的试点项目表明，参加工作坊后压力和抑郁显著降低；这项嵌套研究还表明，这些改善与健康行为的改善呈正相关。这些结果可能对制定干预措施以改善有压力和抑郁的SLE患者的疾病体验和生活质量有启示。
