[四川省藏族僧侣高尿酸血症的流行病学研究及危险因素分析]

[Epidemiology Study and Risk Factors Analysis of Hyperuricemia in Tibetan Monks of Sichuan Province].

作者信息

Lyu Qing-guo, Wang Shi-yu, Zhang Yu-wei, Wei Shi-you, Tang Li-zhi, Zhou Ke-jin, Tong Nan-wei

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Sep;46(5):759-63, 769.

PMID:26619552

Abstract

OBJECTIVE

To investigate the prevalence and risk factors of hyperuricemia (HUA) in Tibetan monks of Sichuan province.

METHODS

755 adult Tibetan monks (more than 18 years old) in Ganzi Tibetan Autonomous Prefecture of Sichuan Province were included in this study for health examination. Residents of Kangding City who received health examination were selected as controls. We measured the height, body mass, waist circumference, hip circumference, blood pressure and detected liver and renal function, serum lipid and blood routine exam. Then HUA prevalence in different genders and ages, and risk factors of HUA were analyzed.

RESULTS

The serum uric acid (SUA) level of Tibetan monks was (318. 03±107. 70) µmol/L with the total HUA prevalence of 21. 46%. The prevalence of male was higher than that of female (25. 44% vs. 19. 02%, P<0. 05). The overall HUA prevalence of residents in Kangding City was 30. 70%, which was higher than that of the monks (P<0. 01). Prevalence of HUA in male monks was lower than the entire male population (25. 44% vs. 41. 65%) and male Tibetan ones (25. 44% vs. 32. 23%) in Kangding city. Among female population, however, we found that the HUA prevalence of monk (19. 02%) was higher than that of overall female population (14. 07%) and Tibetan residents (14. 72%) in Kangding (P<0. 05). Peak prevalence of HUA in Tibetan monks was between 30 and 40 years old. Gender, waist circumference, waist-to-height ratio (WHtR), fasting plasma glucose (FPG), serum creatinine (SCr), hemoglobin (Hb) levels and the consumption of meat were all independent risk factors for the occurrence of HUA in Tibetan monks according to Logistic regression analysis.

CONCLUSION

The prevalence of HUA in male Tibetan monks is lower than that of local urban Tibetan population, but the result in female monks is opposite. Gender, waist circumference, WHtR, FPG, SCr, Hb levels and the consumption of meat were all independent risk factors for HUA.

摘要

目的

调查四川省藏族僧侣高尿酸血症（HUA）的患病率及危险因素。

方法

本研究纳入四川省甘孜藏族自治州755名成年藏族僧侣（年龄大于18岁）进行健康体检。选取接受健康体检的康定市居民作为对照。测量身高、体重、腰围、臀围、血压，并检测肝肾功能、血脂及血常规。然后分析不同性别和年龄的HUA患病率以及HUA的危险因素。

结果

藏族僧侣血清尿酸（SUA）水平为（318.03±107.70）μmol/L，HUA总患病率为21.46%。男性患病率高于女性（25.44%对19.02%，P<0.05）。康定市居民HUA总体患病率为30.70%，高于僧侣（P<0.01）。男性僧侣HUA患病率低于康定市全体男性人群（25.44%对41.65%）及康定市藏族男性（25.44%对32.23%）。然而，在女性人群中，我们发现僧侣的HUA患病率（19.02%）高于康定市全体女性人群（14.07%）及藏族女性居民（14.72%）（P<0.05）。藏族僧侣HUA患病率高峰在30至40岁之间。根据Logistic回归分析，性别、腰围、腰高比（WHtR）、空腹血糖（FPG）、血清肌酐（SCr）、血红蛋白（Hb）水平及肉类摄入量均为藏族僧侣发生HUA的独立危险因素。