Yu Jun-Wen, Yang Tong-Guang, Diao Wei-Xia, Cai Xiao-Qing, Li Ting, Zhong Hua, Hu Da-Lin, Chen Cui-Qing, Chen Zi-Xing
Foshan Hospital of Traditional Chinese Medicine, Foshan 258000, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Aug;31(8):860-2.
To determine the prevalence rates and risk factors of hyperuricemia (HUA) and gout among residents aged over 20 years in Foshan areas.
A randomly stratified cluster sampling was conducted, and 7403 inhabitants were investigated on their prevalence rates of HUA and gout.
(1) The prevalence of HUA was 15.09%, and the standardized rate was 15.27%, in which the prevalence in males was 19.90% and females was 10.54%. The prevalence of gout was 1.04% and the standardized rate was 1.08%, in which the prevalence in males was 1.73% and females was 0.39%. The prevalence of gout in patients with HUA was 6.89%. (2) Average serum uric acid was (336.4 ± 81.5) µmol/L, with (347.1 ± 88.6) µmol/L in males and (289.7 ± 78.6) µmol/L in females. The serum uric acid levels in male patients with HUA was higher than those in women. (3) Age, body mass index, systolic blood pressure, diastolic blood pressure, serum uric acid, blood sugar, triglyceride (TG), total cholesterol were significantly higher in patients with HUA and gout than in the normal group (P < 0.05 - 0.01). The incidence rates of patients with hyperuricemia and gout in the following indices as:overweight and obesity, high blood pressure, high blood sugar were significantly higher than those in the normal group (P < 0.05). Patients having gout in the following indices as age, TG, serum uric acid levels were significantly higher than the HUA group (P < 0.05). (4) Data from non-conditional logistic regression analysis showed that age, overweight, hypertension, diabetes, hyperlipidemia, use of diuretics, family history, alcohol uptake, eating seafood and drinking meat broth, post-menopausal women, and other factors were similar to those factors as patients with hyperuricemia. Tea, fresh vegetables, fruits seemed to be the protective factors.
Both the prevalence rates of HUA and gout had significantly increased in Foshan areas in recent years. Restricting the intake of food with rich purine, alcohol intake as well as controlling obesity and blood pressure, improving the status of lipid metabolic disorder together with programs as hypertension control etc. were important measures in the strategies on prevention and treatment on hyperuricemia and gout.
确定佛山地区20岁以上居民高尿酸血症（HUA）和痛风的患病率及危险因素。
采用随机分层整群抽样法，对7403名居民进行HUA和痛风患病率调查。
（1）HUA患病率为15.09%，标化率为15.27%，其中男性患病率为19.90%，女性为10.54%。痛风患病率为1.04%，标化率为1.08%，其中男性患病率为1.73%，女性为0.39%。HUA患者中痛风患病率为6.89%。（2）血清尿酸平均值为（336.4±81.5）µmol/L，男性为（347.1±88.6）µmol/L，女性为（289.7±78.6）µmol/L。男性HUA患者血清尿酸水平高于女性。（3）HUA和痛风患者的年龄、体重指数、收缩压、舒张压、血清尿酸、血糖、甘油三酯（TG）、总胆固醇均显著高于正常组（P<0.05 - 0.01）。高尿酸血症和痛风患者在超重与肥胖、高血压、高血糖等指标的发生率显著高于正常组（P<0.05）。痛风患者在年龄、TG、血清尿酸水平等指标显著高于HUA组（P<0.05）。（4）非条件logistic回归分析数据显示，年龄、超重、高血压、糖尿病、高脂血症、使用利尿剂、家族史、饮酒、食用海鲜和饮用肉汤、绝经后女性等因素与高尿酸血症患者的因素相似。茶、新鲜蔬菜、水果似乎是保护因素。
近年来佛山地区HUA和痛风的患病率均显著上升。限制高嘌呤食物摄入、控制饮酒以及控制肥胖和血压、改善脂质代谢紊乱状况以及开展高血压控制等项目是高尿酸血症和痛风防治策略中的重要措施。
