Fries S, Pasche P, Brunel C, Schweizer V
Rev Med Suisse. 2015 Sep 30;11(488):1796, 1798-1802.
Amyloidosis consists of different forms of systemic or isolated organ lesions characterised by fibrillary protein deposits in extra-cellular tissue. The isolated involvement of the larynx is the most frequent form in the ENT sphere. We present a clinical case of a 67 year-old woman addressed for a sub-acute laryngitis resistant to conservative treatment, and finally diagnosed with laryngeal amyloidosis. We reviewed its physiopathology, the scientific literature as well as the different possibilities of management. Laryngeal amyloidosis is rare. A thorough additional work-up for the research of multifocal or systemic forms is highly recommended. The treatment aims at a minimal invasive endoscopic surgery with functional organ preservation.
淀粉样变性由不同形式的系统性或孤立性器官病变组成，其特征是细胞外组织中存在纤维状蛋白质沉积。喉部的孤立性受累是耳鼻喉领域最常见的形式。我们报告一例67岁女性的临床病例，该患者因亚急性喉炎接受治疗，对保守治疗耐药，最终被诊断为喉淀粉样变性。我们回顾了其病理生理学、科学文献以及不同的治疗可能性。喉淀粉样变性很罕见。强烈建议对多灶性或系统性形式进行全面的进一步检查。治疗旨在进行微创内镜手术并保留器官功能。
