[Theoretical analysis of mechanisms of occurrence of DNA deletions in prokaryotic genomes based on direct repeats].

In the present work a mechanism of deletions emergence on the basis of complementary DNA regions mispairing of direct repeats has been investigated theoretically. A quantitative dependence of the rates of deletions emergence on such parameters of the flanking repeats as the nucleotide composition of repeats, the number of homology damages and the distance between repeated regions has been constructed. It has been proved, that using this relationship one can reliably evaluate the total rates of deletions emergence in the lacI gene sequence of E. coli according to the repeats arrangement in this gene.