Zabel B
Universität-Kinderklinik, Mainz.
Monatsschr Kinderheilkd. 1989 May;137(5):257-61.
DNA technology opens up new approaches to the treatment of some hereditary diseases. By means of such techniques as retrovirus-mediated gene transfer, cloned human genes may be introduced into the cell genome to correct the defect present in these inherited disorders. Several ethical issues have been raised in the discussion of human gene therapy. There is general consensus that germline gene therapy should not be applied in humans, as the gene manipulation could be passed on to subsequent generations. As reviewed here, laboratories are focusing on concepts relating to somatic gene therapy. This approach involves the insertion of genetic material into somatic cells and is comparable with organ transplantation.
DNA技术为某些遗传性疾病的治疗开辟了新途径。通过逆转录病毒介导的基因转移等技术，可以将克隆的人类基因导入细胞基因组，以纠正这些遗传性疾病中存在的缺陷。在人类基因治疗的讨论中提出了几个伦理问题。人们普遍认为，生殖系基因治疗不应应用于人类，因为基因操作可能会传递给后代。如本文所述，实验室正专注于与体细胞基因治疗相关的概念。这种方法涉及将遗传物质插入体细胞，与器官移植类似。
