Chow Eric P F, Lee David, Tabrizi Sepehr N, Phillips Samuel, Snow Anthony, Cook Stuart, Howden Benjamin P, Petalotis Irene, Bradshaw Catriona S, Chen Marcus Y, Fairley Christopher K
Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Sex Transm Infect. 2016 Aug;92(5):347-9. doi: 10.1136/sextrans-2015-052399. Epub 2015 Nov 30.
This study aimed to determine the proportion of untreated pharyngeal swabs or saliva samples positive by culture or nucleic acid amplification tests (NAATs) for Neisseria gonorrhoeae up to 14 days after an initial culture-positive pharyngeal swab.
Men who have sex with men who tested positive for pharyngeal gonorrhoea at Melbourne Sexual Health Centre (MSHC) and returned to MSHC for treatment within 14 days between 13 October 2014 and 25 March 2015 were included in this study. Pharyngeal swabs and saliva samples were collected for culture and NAAT.
Of 33 initially culture-positive pharyngeal swabs, 32 saliva samples and 31 pharyngeal swabs were positive by NAAT and 14 pharyngeal and 6 saliva samples were positive by culture within 14 days. There was a significant decline in the proportion of repeated pharyngeal culture samples positive by culture over time (p<0.001).
The rapid decline suggests pharyngeal gonorrhoea is short-lived, and the finding of gonorrhoea commonly in the saliva implicates this body fluid in its transmission without direct throat inoculation.
本研究旨在确定在初次咽拭子培养呈阳性后的14天内，未经治疗的咽拭子或唾液样本通过淋病奈瑟菌培养或核酸扩增检测（NAATs）呈阳性的比例。
纳入2014年10月13日至2015年3月25日期间在墨尔本性健康中心（MSHC）咽淋病检测呈阳性且在14天内返回MSHC接受治疗的男男性行为者。采集咽拭子和唾液样本进行培养及NAAT检测。
在33份最初培养呈阳性的咽拭子中，32份唾液样本和31份咽拭子在14天内通过NAAT检测呈阳性，14份咽拭子和6份唾液样本通过培养呈阳性。随着时间推移，重复咽拭子培养样本中培养呈阳性的比例显著下降（p<0.001）。
快速下降表明咽淋病持续时间短，并且在唾液中常见淋病奈瑟菌这一发现表明该体液在其传播中起作用，而无需直接接种到咽喉。
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