Bijak M, Smiałowski A
Polish Academy of Sciences, Institute of Pharmacology, Kraków.
Pharmacol Biochem Behav. 1989 Mar;32(3):585-7. doi: 10.1016/0091-3057(89)90001-4.
The effect of SCH 23390 administration on the serotonin system-dependent head twitch behavior was studied in the rat. A small dose of SCH 23390 (1.25 micrograms/kg), injected 20 min before the test, decreased the number of quipazine-induced head twitches. Repeated treatment with SCH 23390 (0.5 mg/kg, SC), once a day for 18 days, increased the number of spontaneously occurring and quipazine-induced head twitches. The enhancing effect of repeated administration of SCH 23390 was blocked by cyproheptadine (0.4 mg/kg). The results indicate that acute injection of SCH 23390 blocks central serotonin receptors, whereas repeated treatment induces their functional supersensitivity.
在大鼠中研究了给予SCH 23390对5-羟色胺系统依赖性头部抽搐行为的影响。在测试前20分钟注射小剂量的SCH 23390（1.25微克/千克），可减少喹哌嗪诱导的头部抽搐次数。每天一次重复给予SCH 23390（0.5毫克/千克，皮下注射），持续18天，可增加自发出现的和喹哌嗪诱导的头部抽搐次数。赛庚啶（0.4毫克/千克）可阻断重复给予SCH 23390的增强作用。结果表明，急性注射SCH 23390可阻断中枢5-羟色胺受体，而重复给药则诱导其功能超敏反应。
