Lucki I, Minugh-Purvis N
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
Brain Res. 1987 Sep 15;420(2):403-6. doi: 10.1016/0006-8993(87)91265-0.
Serotonin-induced head shaking behavior, a response associated with 5-HT2 receptors, was examined in rats with lesions of the frontal cortex because of the high density of 5-HT2 receptors in this area. Head shaking behavior caused by the serotonin precursor, 5-hydroxy-L-tryptophan, or by the serotonergic agonist, quipazine, was unchanged following the complete ablation of the frontal cortex. Although 5-HT2 receptors are associated with the head shake response, this behavior is probably not related to serotonin receptors located in the frontal cortex.
由于额叶皮质中5-HT2受体密度高，因此在额叶皮质受损的大鼠中研究了与5-HT2受体相关的血清素诱导的摇头行为。血清素前体5-羟基-L-色氨酸或血清素能激动剂喹哌嗪引起的摇头行为在额叶皮质完全切除后未发生变化。虽然5-HT2受体与摇头反应有关，但这种行为可能与位于额叶皮质的血清素受体无关。
