Amra Babak, Borougeni Victoria Beigi, Golshan Mohammad, Soltaninejad Forogh
Bamdad Respiratory and Sleep Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2015 Jul;20(7):697-700. doi: 10.4103/1735-1995.166229.
Several studies have showed an increased prevalence of airflow obstruction in first degree relatives of individuals with chronic obstructive pulmonary disease (COPD). Considering no specific research had evaluated airway resistance in offspring of patients with severe COPD, we utilized a spirometry and a impulse oscillometry (IO) to evaluate this population.
In this case control study, from November 2011 to July 2012, we consecutively evaluated 54 offsprings of severe COPD patients (case group) admitted in the pulmonary ward, affiliated to the Isfahan University of Medical Sciences and control group. Pulmonary function tests and the IO were obtained for both groups. Student's t-test was used for inter-group comparisons, and P values below 0.05 were taken as significant.
Abnormal increased airway resistance was seen in cases in comparison with controls (R5 Hz [46.29%, P = 0.01], R25 Hz [42.59%, P < 0.001]). Also, considering the spirometry, case group had pulmonary function parameters less than control group (forced vital capacity [FVC]; P = 0.02, forced expiratory volume in 1(st) s; P < 0.001, forced expiratory flow (FEF) 25-75; P < 0.001, FEF 25-75/FVC; P < 0.001) but they were in normal range.
This study demonstrated increased airway resistance among the severe COPD offsprings. The IO may be a sensitive tool for detection of high risk subjects in families with COPD.
多项研究表明，慢性阻塞性肺疾病（COPD）患者的一级亲属中气流受限的患病率有所增加。鉴于尚无具体研究评估重度COPD患者后代的气道阻力，我们采用肺活量测定法和脉冲振荡法（IO）对这一人群进行评估。
在这项病例对照研究中，从2011年11月至2012年7月，我们连续评估了伊斯法罕医科大学附属肺科病房收治的54例重度COPD患者的后代（病例组）和对照组。两组均进行了肺功能测试和IO检测。采用学生t检验进行组间比较，P值低于0.05被视为具有统计学意义。
与对照组相比，病例组气道阻力异常增加（5Hz时的气道阻力R5Hz[46.29%，P = 0.01]，25Hz时的气道阻力R25Hz[42.59%，P < 0.001]）。此外，根据肺活量测定结果，病例组的肺功能参数低于对照组（用力肺活量[FVC]；P = 0.02，第1秒用力呼气量；P < 0.001，25%～75%用力呼气流量[FEF]；P < 0.001，FEF 25-75/FVC；P < 0.001），但仍处于正常范围。
本研究表明重度COPD患者后代的气道阻力增加。IO可能是检测COPD家族中高危个体的敏感工具。
