Amra Babak, Asadi Mehrnaz, Salehi Hassan, Zamani Ahmad R, Golshan Mohammad
Isfahan University of Medical Sciences, Isfahan, Iran.
Respirology. 2006 Jul;11(4):477-81. doi: 10.1111/j.1440-1843.2006.00876.x.
Transfer factor or carbon monoxide diffusing capacity (DL(CO)) is a particularly valuable test of the appropriateness of gas exchange across the alveolocapillary membrane. The purpose of this study is to derive predictive equations for DL(CO) and its derivative volume-corrected DL(CO) (DL(CO)/VA) measured by single-breath method in a large non-smoking population sample in Isfahan.
We evaluated 1429 randomly selected subjects (732 men, aged 5-85 years). Gender-specific linear prediction equations were developed by multiple regression analysis; with measured DL(CO), and DL(CO)/VA values (mmol/min/kPa), as dependent variables regressed against age (A), height (H) and body surface area (BSA).
For both genders, age had negative effects on DL(CO), while height had a positive effect on DL(CO) and DL(CO)/VA (P < 0.01). The prediction equations for DL(CO) and DL(CO)/VA are: '0.152 x height - 0.056 x age - 11.595' and '-0.12 x age + 2.467', for men and: '-0.035 x age - 0.133 x height - 10.707' and '-0.012 x age - 0.02 x height + 2.755', for women, respectively.
Our results therefore provide an original frame of reference for either DL(CO) or DL(CO)/VA in Iranian population, obtained from a standardized single-breath technique.
转运因子或一氧化碳弥散量（DL(CO)）是评估肺泡毛细血管膜气体交换适宜性的一项特别有价值的检测指标。本研究的目的是在伊斯法罕的大量非吸烟人群样本中，推导出通过单次呼吸法测量的DL(CO)及其衍生指标容积校正后的DL(CO)（DL(CO)/VA）的预测方程。
我们评估了1429名随机选取的受试者（732名男性，年龄在5至85岁之间）。通过多元回归分析建立了性别特异性线性预测方程；以测量的DL(CO)和DL(CO)/VA值（mmol/min/kPa）作为因变量，对年龄（A）、身高（H）和体表面积（BSA）进行回归分析。
对于男性和女性，年龄对DL(CO)均有负面影响，而身高对DL(CO)和DL(CO)/VA均有正面影响（P < 0.01）。男性的DL(CO)和DL(CO)/VA的预测方程分别为：“0.152×身高 - 0.056×年龄 - 11.595”和“ - 0.12×年龄 + 2.467”；女性的分别为：“ - 0.035×年龄 - 0.133×身高 - 10.707”和“ - 0.012×年龄 - 0.02×身高 + 2.755”。
因此，我们的研究结果为伊朗人群中DL(CO)或DL(CO)/VA提供了一个源自标准化单次呼吸技术的原始参考框架。
