Su Wen-Jing, Fang Sheng, Chen Ai-Jun, Shan Kui
Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Exp Ther Med. 2015 Oct;10(4):1533-1535. doi: 10.3892/etm.2015.2668. Epub 2015 Aug 3.
Scabies is a contagious skin disease that causes extremely itching. It is a parasitic disease caused by the mite and characterized by polymorphous lesions. Vesicular and bullous lesions in cases of scabies are rather rare. Bullous scabies has a pemphigoid presentation. Crusted scabies, also known as Norwegian scabies, is a rare and severe form of the disease. The large number of mites present in and on the skin cause scabies to be highly contagious. The present study reports a case of crusted scabies combined with bullous scabies, the clinical and histopathological manifestations of which mimicked those of bullous pemphigoid. Direct and indirect immunofluorescence test results were negative. Bullae recurred and persisted despite systemic corticosteroids and antihistamine medication. The patient was successfully treated with 10% sulfur cream and remained free of recurrence during the 12 months of follow-up. Differential diagnosis with bullous pemphigoid and the mechanism of formation of bullae are also discussed.
疥疮是一种具有传染性的皮肤病,会引起剧烈瘙痒。它是由螨虫引起的寄生虫病,其特征为多形性皮损。疥疮病例中的水疱性和大疱性皮损相当罕见。大疱性疥疮具有类天疱疮表现。结痂性疥疮,也称为挪威疥疮,是该疾病的一种罕见且严重的形式。皮肤内外存在的大量螨虫致使疥疮具有高度传染性。本研究报告了一例结痂性疥疮合并大疱性疥疮的病例,其临床和组织病理学表现与大疱性类天疱疮相似。直接和间接免疫荧光试验结果均为阴性。尽管使用了全身性皮质类固醇和抗组胺药物治疗,大疱仍反复出现并持续存在。该患者用10%硫磺乳膏成功治愈,在12个月的随访期间未再复发。文中还讨论了与大疱性类天疱疮的鉴别诊断以及大疱形成的机制。