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结痂性疥疮与大疱性疥疮合并:1例罕见病例

Combination of Crusted Scabies with Bullous Scabies: A Rare Case.

作者信息

Asnawi Vella, Maulida Mimi, Hidayati Arie, Gunawan Hendra, Dwiyana Reiva Farah, Hindritiani Reti

机构信息

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, Indonesia.

Department of Dermatology and Venereology, Dr. Zainoel Abidin General Hospital, Banda Aceh, Aceh, Indonesia.

出版信息

Int Med Case Rep J. 2023 Mar 11;16:153-158. doi: 10.2147/IMCRJ.S396234. eCollection 2023.

DOI:10.2147/IMCRJ.S396234
PMID:36936186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10018284/
Abstract

Scabies is a parasitic skin disease caused by . Crusted scabies, also known as Norwegian scabies, is a rare and severe form of scabies that occurs more frequently in immunocompromised, elderly, disabled, and debilitated patients. The present study reports a case of crusted scabies combined with bullous scabies. A 44-year-old man was admitted with the chief complaint of red, thick, scaly patches of skin accompanied by crusting that felt itchy and worsened at night. The lesions had appeared all over his body intermittently for the last 10 years; however, the complaints worsened in the last 2 months. From dermatological status, the anterior and posterior thoracic regions and between the fingers of both hands showed generalized distribution of erythematous, yellowish, hyperkeratotic plaques with clear boundaries, pustules, and blisters on an erythematous base with multiple erosions and excoriations. were found on skin scraping examination, and histopathological examination supported the diagnosis of bullous scabies. The patient received 5% permethrin lotion topical therapy and systemic ivermectin therapy. In addition, the patient was given systemic antibiotics. The lesions improved after 2 weeks of therapy, and no were found on the subsequent microscopic examination. Treatment with a combination of topical and systemic scabicidal agents produced a favorable outcome in this patient.

摘要

疥疮是一种由……引起的寄生虫性皮肤病。结痂性疥疮,也称为挪威疥疮,是一种罕见且严重的疥疮形式,在免疫功能低下、老年人、残疾人和体弱患者中更常见。本研究报告了一例结痂性疥疮合并大疱性疥疮的病例。一名44岁男性因皮肤出现红色、增厚、鳞屑状斑块并伴有结痂,伴有瘙痒且夜间加重为主诉入院。在过去10年中,这些皮疹间歇性地出现在他全身;然而,在过去2个月中症状加重。从皮肤病学状况来看,前胸和后背区域以及双手手指间可见边界清晰的红斑、淡黄色、角化过度斑块广泛分布,在红斑基础上有脓疱和水疱,伴有多处糜烂和抓痕。皮肤刮片检查发现……,组织病理学检查支持大疱性疥疮的诊断。患者接受了5%氯菊酯洗剂局部治疗和全身性伊维菌素治疗。此外,还给患者使用了全身性抗生素。治疗2周后皮损改善,随后的显微镜检查未发现……。局部和全身性杀疥剂联合治疗在该患者中取得了良好效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/8264a7513021/IMCRJ-16-153-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/86c1386639d1/IMCRJ-16-153-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/2ca5fcde6754/IMCRJ-16-153-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/bf627b7e5d78/IMCRJ-16-153-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/8b958b7aa3b1/IMCRJ-16-153-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/38faa42af4c7/IMCRJ-16-153-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/8264a7513021/IMCRJ-16-153-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/86c1386639d1/IMCRJ-16-153-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/2ca5fcde6754/IMCRJ-16-153-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/bf627b7e5d78/IMCRJ-16-153-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/8b958b7aa3b1/IMCRJ-16-153-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/38faa42af4c7/IMCRJ-16-153-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11c3/10018284/8264a7513021/IMCRJ-16-153-g0006.jpg

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本文引用的文献

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Bullous Scabies: Clinical, Dermoscopic, and Pathologic Characteristics of Ten Patients.大疱性疥疮:十例患者的临床、皮肤镜和病理特征。
Am J Trop Med Hyg. 2021 Sep 7;105(6):1798-1802. doi: 10.4269/ajtmh.21-0516.
2
Infestation. What Is Already Known, and What Is New about Scabies at the Beginning of the Third Decade of the 21st Century?疥疮。在21世纪第三个十年伊始,关于疥疮已知的情况以及新的发现有哪些?
Pathogens. 2021 Jul 9;10(7):868. doi: 10.3390/pathogens10070868.
3
Crusted scabies; a 2-year prospective study from the Northern Territory of Australia.
结痂性疥疮;来自澳大利亚北部地区的一项为期 2 年的前瞻性研究。
PLoS Negl Trop Dis. 2020 Dec 18;14(12):e0008994. doi: 10.1371/journal.pntd.0008994. eCollection 2020 Dec.
4
Ectoparasites: Scabies.体外寄生虫:疥疮。
J Am Acad Dermatol. 2020 Mar;82(3):533-548. doi: 10.1016/j.jaad.2019.05.109. Epub 2019 Jul 13.
5
Norwegian scabies.挪威疥疮
Cleve Clin J Med. 2019 Mar;86(3):163-164. doi: 10.3949/ccjm.86a.18081.
6
A case of crusted scabies combined with bullous scabies.1例结痂性疥疮合并大疱性疥疮。
Exp Ther Med. 2015 Oct;10(4):1533-1535. doi: 10.3892/etm.2015.2668. Epub 2015 Aug 3.
7
Scabies: an ancient global disease with a need for new therapies.疥疮:一种古老的全球性疾病,需要新的治疗方法。
BMC Infect Dis. 2015 Jul 1;15:250. doi: 10.1186/s12879-015-0983-z.
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Bullous scabies: a case report and review of the literature.大疱性疥疮:一例病例报告及文献综述
BMC Res Notes. 2015 Jun 20;8:254. doi: 10.1186/s13104-015-1146-4.
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Crusted scabies.结痂性疥疮
Indian Pediatr. 2014 Aug;51(8):680.
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Scabies: a review of diagnosis and management based on mite biology.疥疮:基于螨生物学的诊断与管理综述
Pediatr Rev. 2012 Jan;33(1):e1-e12. doi: 10.1542/pir.33-1-e1.