Yang Wenyan, Sun Fuguang, Liu Hongjun, Wang Guangjian, Shi Peiqing, Shao Zhiqiang, Guo Fengfu
Department of Urology, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.
Department of Urology, The First Affiliated Hospital of The General Hospital of the People's Liberation Army, Beijing 100037, P.R. China.
Oncol Lett. 2015 Sep;10(3):1617-1619. doi: 10.3892/ol.2015.3379. Epub 2015 Jun 16.
Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide. In the present study, a prostate SFT case, which was initially misdiagnosed as benign prostatic hyperplasia, is presented. The patient was subjected to three surgeries (cystoscopy and per urethra lithocystotomy, transurethral resection of the prostate and nerve-sparing retropubic radical prostatectomy) prior to SFT diagnosis. It was demonstrated that histopathological and immunohistochemical factors (positive staining for CD34 and B cell lyphoma-2 expression) were of significant diagnostic value. Thus, nerve-sparing retropubic radical prostatectomy for total resection may be the best therapeutic strategy to treat prostate SFT, allowing the preservation of sexual function and reducing the risk of locoregional recurrence.
在过去十年中,包括前列腺孤立性纤维性肿瘤(SFT)在内的胸膜外孤立性纤维性肿瘤的报告数量不断增加。前列腺SFT相对少见,全球文献报道的病例不足20例。在本研究中,报告了一例最初被误诊为良性前列腺增生的前列腺SFT病例。该患者在SFT诊断之前接受了三次手术(膀胱镜检查和经尿道膀胱结石切除术、经尿道前列腺切除术以及保留神经的耻骨后根治性前列腺切除术)。结果表明,组织病理学和免疫组化因素(CD34阳性染色和B细胞淋巴瘤-2表达)具有重要的诊断价值。因此,保留神经的耻骨后根治性前列腺切除术以实现完全切除可能是治疗前列腺SFT的最佳治疗策略,可保留性功能并降低局部复发风险。