van der Molen E J, van Lieshout J H, Nabuurs M J, Derkx F H, Lamers A P, Michelakis A M
Central Veterinary Institute, Lelystad, The Netherlands.
Res Vet Sci. 1989 May;46(3):401-5.
Carbadox is known to induce toxic effects on the adrenal cortex, resulting in hypoaldosteronism. To study the involvement of carbadox on the renin-angiotensin system, weaned piglets of five weeks old received feed supplemented with 0 (control group), 50, 100, 150 or 200 ppm carbadox. After four weeks the 100 and 150 ppm groups had significantly higher plasma renin activity levels than the control group and after nine weeks plasma renin activity levels of all treated groups were significantly higher than the control group. Five and 10 weeks after carbadox administration, three and two pigs, respectively, of all groups were necropsied and the kidneys were screened for immunohistochemically demonstrated renin. All dosed pigs demonstrated an increase of immunoreactive renin, which was dose- and time-related. From these results it is concluded that carbadox induces activation of the renin-angiotensin system, secondary to the suppressing effect on mineralocorticoid secretion and that these changes may be responsible for part of the clinical picture.
已知卡巴多司会对肾上腺皮质产生毒性作用，导致醛固酮减少症。为了研究卡巴多司对肾素-血管紧张素系统的影响，给五周龄的断奶仔猪喂食添加了0（对照组）、50、100、150或200 ppm卡巴多司的饲料。四周后，100 ppm和150 ppm组的血浆肾素活性水平显著高于对照组，九周后，所有处理组的血浆肾素活性水平均显著高于对照组。在给予卡巴多司五周和十周后，分别对所有组的三头和两头猪进行尸检，并对肾脏进行免疫组织化学检测以显示肾素。所有给药猪的免疫反应性肾素均增加，且与剂量和时间相关。从这些结果可以得出结论，卡巴多司会继发于对盐皮质激素分泌的抑制作用而诱导肾素-血管紧张素系统的激活，并且这些变化可能是临床症状的部分原因。
