van der Molen E J, de Graaf G J, Baars A J
Central Veterinary Institute, Lelystad, The Netherlands.
J Comp Pathol. 1989 Apr;100(3):295-304. doi: 10.1016/0021-9975(89)90107-2.
This study was performed to investigate the persistence of carbadox-induced adrenal lesions in pigs after withdrawal of the drug. Six groups (N = 13) received 0 (control group), 25, 50, 100 and 200 ppm carbadox. After 10 weeks, carbadox was withdrawn from the feed. Five and 11 weeks after withdrawal, two pigs per group were necropsied and the adrenals were examined histologically. Five weeks after withdrawal, recovery of lesions was seen in the 25 and 50 ppm groups. In the 100 and 150 ppm groups, adrenal changes were still present. After 11 weeks an incomplete recovery occurred in the 100 ppm group and in one of the pigs from the 150 ppm group; the second pig of this group still demonstrated moderate changes. Pigs from the 200 ppm group showed severe changes and absence of a clear zonal differentiation. Plasma aldosterone values started to recover 2 weeks after withdrawal of carbadox. Histological examination suggested stimulation of the aldosterone-producing glomerular zone, eventually resulting in regressive changes. The mechanisms that possibly induced this continuous stimulation are discussed.
本研究旨在调查停药后卡巴多司诱导的猪肾上腺病变的持续情况。六组（每组13头猪）分别给予0（对照组）、25、50、100和200 ppm的卡巴多司。10周后，从饲料中撤去卡巴多司。停药后5周和11周，每组剖检2头猪，并对肾上腺进行组织学检查。停药5周后，25 ppm和50 ppm组的病变有所恢复。100 ppm和150 ppm组仍存在肾上腺变化。11周后，100 ppm组及150 ppm组的一头猪出现不完全恢复；该组的另一头猪仍表现出中度变化。200 ppm组的猪表现出严重变化且无明显的带区分化。卡巴多司停药2周后血浆醛固酮值开始恢复。组织学检查提示醛固酮分泌性球状带受到刺激，最终导致退行性变化。文中讨论了可能导致这种持续刺激的机制。
