Shoghli Alireza, Nabavi Seyed Mahmood, Alavian Seyed Moayed, Kolifarhood Goodarz, Goya Mohammad Mehdi, Namazi Roshanak, Fallahnezhad Mojtaba, Mohajeri Mansor, Mousavinasab Nouraldin, Zanjani Rahim Sorouri, Saeini Mohammad Reza, Jalilvand Ahmad
Department of Social Medicine, Zanjan University of Medical Sciences and Health Services, Zanjan, Iran.
Department of Tropical and Infectious Diseases, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran.
Int J Prev Med. 2014 Dec;5(Suppl 3):S213-8.
Vertical transmission of hepatitis B virus (HBV) from infected mothers to their neonates is one of the most important routes of infection. The exact prevalence rate of HBV in Iranian pregnant mothers is not well known but based on different studies it is estimated between 0.35% and 6.5%. The aim of this study was to determine the seroprevalence of hepatitis B surface antigen (HBsAg) in pregnant women of selected provinces in Iran.
At this cross-sectional study, seven provinces supposed to be of high and low prevalence of hepatitis B in the general population selected. Multistage sampling was used to enroll 5261 parturient women who attended the target provinces birth facilities, during January to March of 2011, were recruited to study. To determine the statistically significant mean and proportion differences, t-test and χ (2) test were used, respectively.
Overall 1.2% was positive HBsAg of which 11% of them were hepatitis B e-antigen positive as well. The eastern and north eastern provinces were considerably higher in HBsAg seropositivity than the west and northwest of the country.
In view of the considerable prevalence of hepatitis B in pregnant women, screening all pregnant women prioritizing the eastern and north-eastern provinces is strongly recommended.
乙型肝炎病毒（HBV）从感染母亲垂直传播给新生儿是最重要的感染途径之一。伊朗孕妇中HBV的确切流行率尚不清楚，但根据不同研究估计在0.35%至6.5%之间。本研究的目的是确定伊朗选定省份孕妇中乙肝表面抗原（HBsAg）的血清流行率。
在这项横断面研究中，选择了七个在一般人群中乙肝流行率高低不同的省份。采用多阶段抽样方法，纳入2011年1月至3月期间在目标省份分娩设施就诊的5261名产妇进行研究。分别使用t检验和χ²检验来确定具有统计学意义的均值和比例差异。
总体而言，1.2%的人HBsAg呈阳性，其中11%的人乙肝e抗原也呈阳性。东部和东北部省份的HBsAg血清阳性率明显高于该国西部和西北部。
鉴于孕妇中乙肝流行率较高，强烈建议对所有孕妇进行筛查，优先考虑东部和东北部省份。
