Khan Mohd Ashif, Bhurani Dinesh, Agarwal Nidhi B
Department of Pharmaceutical Medicine, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), India E-mail :
Asian Pac J Cancer Prev. 2015;16(17):7701-5. doi: 10.7314/apjcp.2015.16.17.7701.
Thyroid hormones (TH) are regulated by the hypothalamic-pituitary axis, which plays an important role in cell growth, differentiation, development and other aspects of metabolism. It is believed that an active hypothalamic-pituitary axis increases the susceptibility of thyroid dysfunction during systemic chemotherapy. In order to investigate the relation between thyroid function and chemotherapy the present study was designed to investigate TH in breast cancer patients receiving at least three cycles of chemotherapy. The levels of TH were measured at the baseline and before each cycle of chemotherapy.
Blood samples for estimation of TH levels were collected from 80 (pre-menopausal-40; post-menopausal-40) breast cancer patients just before they were undergoing--1st, 2nd, 3rd and 4th cycle of chemotherapy. The serum was separated and T3, T4 and TSH levels were determined by chemiluminescence method.
T3 and T4 were found significantly decreased and TSH was found significantly increased after 1st (p<0.001), 2nd (p<0.0001) and 3rd cycle of chemotherapy (p<0.0001). The variation of T3 levels (decreased) and TSH levels (increased) was found more in post-menopausal (p<0.0001) women then in pre-menopausal women after 3rd cycle of chemotherapy as compared to baseline (p<0.001).
TH were remarkably altered after each cycle of chemotherapy leading to decline in thyroid function of breast cancer patients. Further, the results also indicated that post- menopausal women were more prone towards decline in thyroid function then pre-menopausal women. The present study proposes the monitoring of TH after each cycle of chemotherapy in breast cancer patients.
甲状腺激素（TH）受下丘脑 - 垂体轴调节，该轴在细胞生长、分化、发育及代谢的其他方面发挥重要作用。据信，活跃的下丘脑 - 垂体轴会增加全身化疗期间甲状腺功能障碍的易感性。为了研究甲状腺功能与化疗之间的关系，本研究旨在调查接受至少三个化疗周期的乳腺癌患者的甲状腺激素情况。在基线时以及每个化疗周期前测量甲状腺激素水平。
从80名（绝经前40名；绝经后40名）乳腺癌患者在即将接受第1、2、3和4周期化疗前采集用于评估甲状腺激素水平的血样。分离血清，采用化学发光法测定T3、T4和TSH水平。
在第1周期（p<0.001）、第2周期（p<0.0001）和第3周期化疗后（p<0.0001），发现T3和T4显著降低，TSH显著升高。与基线相比，在第3周期化疗后，绝经后女性（p<0.0001）的T3水平变化（降低）和TSH水平变化（升高）比绝经前女性更明显（p<0.001）。
每个化疗周期后甲状腺激素均发生显著改变，导致乳腺癌患者甲状腺功能下降。此外，结果还表明绝经后女性比绝经前女性更容易出现甲状腺功能下降。本研究建议对乳腺癌患者在每个化疗周期后监测甲状腺激素。
