来自日本绣线菊的二萜生物碱和二萜及其抗烟草花叶病毒活性。

Diterpene alkaloids and diterpenes from Spiraea japonica and their anti-tobacco mosaic virus activity.

作者信息

Ma Yuan, Mao Xin-Ying, Huang Lie-Jun, Fan Yi-Min, Gu Wei, Yan Chen, Huang Tao, Zhang Jian-Xin, Yuan Chun-Mao, Hao Xiao-Jiang

机构信息

School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, People's Republic of China; The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Guiyang 550002, People's Republic of China.

The Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Science, Guiyang 550002, People's Republic of China.

出版信息

Fitoterapia. 2016 Mar;109:8-13. doi: 10.1016/j.fitote.2015.11.019. Epub 2015 Nov 26.

DOI:10.1016/j.fitote.2015.11.019

PMID:26625838

Abstract

Five new naturally occurring natural products, including two atisine-type diterpene alkaloids (1 and 2), two atisane-type diterpenes (3 and 4), and a new natural product spiramine C2 (5), along with nine known ones (6-14), were isolated from the ethanolic extracts of the whole plant of Spiraea japonica var. acuminata Franch. Their structures were elucidated by extensive spectroscopic analysis. The anti-tobacco mosaic virus (TMV) activities of all the compounds were evaluated by the conventional half-leaf method. Six compounds (2, 3, 6, 7, 11, and 12) exhibited moderate activities at 100 μg/mL with inhibition rates in the range of 69.4-92.9%, which were higher than that of the positive control, ningnanmycin. Their preliminary structure-activity relationships were also discussed.

摘要

从尖叶绣线菊全株乙醇提取物中分离得到5个新的天然产物，包括2个atisine型二萜生物碱（1和2）、2个atisane型二萜（3和4）以及1个新天然产物spiramine C2（5），同时还得到9个已知化合物（6 - 14）。通过广泛的光谱分析确定了它们的结构。采用常规半叶法对所有化合物的抗烟草花叶病毒（TMV）活性进行了评价。6个化合物（2、3、6、7、11和12）在100 μg/mL时表现出中等活性，抑制率在69.4% - 92.9%之间，高于阳性对照宁南霉素。还讨论了它们初步的构效关系。