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内生拟茎点霉代谢产物及其抗 TM V 活性

Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity.

机构信息

Key Laboratory of Bio-Pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

出版信息

Molecules. 2017 Nov 27;22(12):2073. doi: 10.3390/molecules22122073.

DOI:10.3390/molecules22122073
PMID:29186928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149851/
Abstract

The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A-C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.

摘要

基于系统发育分析，从内生真菌中发酵和分离代谢产物，鉴定出 6 种化合物，包括多硫酮 A-C 和 H，以及细胞色素酮 C 和 U。其中，细胞色素酮 U 对烟草花叶病毒（TMV）表现出很强的抑制活性。此外，粗提物和纯化的胞外多糖也被证明对病毒感染具有很强的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/aeb5ccf5c2c4/molecules-22-02073-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/d3fe12389eae/molecules-22-02073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/bfe770ac92aa/molecules-22-02073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/3e908d0b9c4b/molecules-22-02073-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/aeb5ccf5c2c4/molecules-22-02073-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/d3fe12389eae/molecules-22-02073-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/bfe770ac92aa/molecules-22-02073-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/3e908d0b9c4b/molecules-22-02073-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/227f/6149851/aeb5ccf5c2c4/molecules-22-02073-g004.jpg

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