Tugrul Selahattin, Koçyiğit Abdurrahim, Doğan Remzi, Eren Sabri Baki, Senturk Erol, Ozturan Orhan, Ozar Omer Faruk
Department of Otorhinolaryngology, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Department of Medical Biochemistry, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Int J Dermatol. 2016 Mar;55(3):e130-5. doi: 10.1111/ijd.13101. Epub 2015 Dec 1.
Recurrent aphthous stomatitis is an idiopathic, chronic, recurrent inflammatory disease of the oral mucosa. It is thought that oxidative stress caused by systemic inflammation plays a basic role in the etiopathogenesis of recurrent aphthous stomatitis. The aim of this study is to review oxidative status and DNA damage in recurrent aphthous stomatitis.
The study included 42 patients with an active recurrent aphthous stomatitis lesion and 39 healthy volunteers with similar demographic characteristics. DNA damage was analyzed using alkaline single cell gel electrophoresis (comet assay). Plasma levels of total antioxidant status and total oxidative status were determined by using an automated measurement method. Oxidative stress index was calculated as total oxidative status/total antioxidant status and × 100.
The total oxidative status and oxidative stress index values were significantly higher in the recurrent aphthous stomatitis group compared to the control group, while total antioxidant status values were significantly lower. In the recurrent aphthous stomatitis group, DNA damage was observed to be significantly higher than the control group. In correlation analysis, significant correlation was found between DNA damage and the oxidative stress index and total oxidative status values in the recurrent aphthous stomatitis group.
This is the first report in the literature that demonstrates association of recurrent aphthous stomatitis with increased oxidative status.
复发性阿弗他口炎是一种口腔黏膜特发性、慢性、复发性炎症性疾病。系统性炎症引起的氧化应激被认为在复发性阿弗他口炎的发病机制中起基本作用。本研究的目的是综述复发性阿弗他口炎中的氧化状态和DNA损伤。
该研究纳入了42例患有活动性复发性阿弗他口炎病变的患者和39例具有相似人口统计学特征的健康志愿者。使用碱性单细胞凝胶电泳（彗星试验）分析DNA损伤。采用自动测量方法测定血浆总抗氧化状态和总氧化状态水平。氧化应激指数计算为总氧化状态/总抗氧化状态×100。
与对照组相比，复发性阿弗他口炎组的总氧化状态和氧化应激指数值显著更高，而总抗氧化状态值显著更低。在复发性阿弗他口炎组中，观察到DNA损伤显著高于对照组。在相关性分析中，复发性阿弗他口炎组的DNA损伤与氧化应激指数和总氧化状态值之间存在显著相关性。
这是文献中首次证明复发性阿弗他口炎与氧化状态增加相关的报告。
