Öztekin Aynure, Öztekin Coşkun, Şahin Hümeyra Nursel, Karadeniz Tuba Betül, Şenel Engin, Çalişkan Ataç Damla, Savci Ünsal, Neşelioğlu Salim, Erel Özcan
Department of Dermatology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Family Medicine Clinic, Sincan Education and Research Hospital, Ankara, Turkey.
Medicine (Baltimore). 2025 Jul 18;104(29):e43403. doi: 10.1097/MD.0000000000043403.
Recurrent aphthous stomatitis is an inflammatory disease characterized by painful ulcers on the oral mucosa. Oxidative stress is held responsible for the pathogenesis of this disease of unknown etiology. In oxidative stress, the balance between oxidant-antioxidant substances changes in favor of the oxidative side. Ischaemia modified albumin (IMA) is a new type of albumin. It occurs as a result of factors such as ischemic attacks and oxidative stress. The aim of the study was to compare IMA levels in patients with recurrent aphthous stomatitis with healthy volunteers and to investigate whether IMA has a diagnostic value in the disease. This cross-sectional study included 32 patients with recurrent aphthous stomatitis and 34 healthy volunteers of similar age and sex. Albumin and IMA levels were determined by spectrophotometric albumin cobalt binding assay in venous blood samples on the same day. IMA was expressed as absorbance unit. Receiver operating characteristic analysis was used to determine whether IMA values could be a diagnostic marker for prediction of disease. IMA values of the patient group were significantly higher than IMA values of the control group (P < .001). IMA was statistically significant in the prediction of recurrent aphthous stomatitis (P < .001). The discrimination power for IMA was very good (area under the receiver operating characteristic curve 95% CI = 0.952 [0.897-1.000]). Recurrent aphthous stomatitis, in which oxidative stress plays a role in the etiopathogenesis, is closely associated with high IMA levels. IMA levels may have diagnostic value as an indicator of oxidative stress in the disease.
复发性阿弗他口炎是一种以口腔黏膜疼痛性溃疡为特征的炎症性疾病。氧化应激被认为是这种病因不明疾病发病机制的原因。在氧化应激中，氧化-抗氧化物质之间的平衡向氧化方向改变。缺血修饰白蛋白（IMA）是一种新型白蛋白。它是由缺血发作和氧化应激等因素导致产生的。本研究的目的是比较复发性阿弗他口炎患者与健康志愿者的IMA水平，并研究IMA在该疾病中是否具有诊断价值。这项横断面研究纳入了32例复发性阿弗他口炎患者和34名年龄及性别相仿的健康志愿者。在同一天采集静脉血样本，通过分光光度法白蛋白钴结合试验测定白蛋白和IMA水平。IMA以吸光度单位表示。采用受试者工作特征分析来确定IMA值是否可作为疾病预测的诊断标志物。患者组的IMA值显著高于对照组（P < 0.001）。IMA在复发性阿弗他口炎的预测中具有统计学意义（P < 0.001）。IMA的辨别能力非常好（受试者工作特征曲线下面积95%CI = 0.952 [0.897 - 1.000]）。氧化应激在发病机制中起作用的复发性阿弗他口炎与高IMA水平密切相关。IMA水平可能作为该疾病氧化应激指标具有诊断价值。
