微小RNA-7a-2基因rs1143770C>T与手术切除的非小细胞肺癌的预后相关。
The pri-let-7a-2 rs1143770C>T is associated with prognosis of surgically resected non-small cell lung cancer.
作者信息
Shin Kyung Min, Jung Deuk Kju, Hong Mi Jeong, Kang Hyo Jung, Lee Won Kee, Yoo Seung Soo, Lee Shin Yup, Cha Seung Ick, Lee Jaehee, Kim Chang Ho, Seok Yangki, Cho Sukki, Son Ji Woong, Lee Eung Bae, Jheon Sanghoon, Kim Young Tae, Park Jae Yong
机构信息
Department of Radiology, Kyungpook National University School of Medicine, Daegu 700-842, Republic of Korea.
Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu 700-842, Republic of Korea.
出版信息
Gene. 2016 Feb 15;577(2):148-52. doi: 10.1016/j.gene.2015.11.036. Epub 2015 Nov 25.
BACKGROUND
Evidence indicates that let-7 of microRNA may be a prognostic factor in lung cancer. Genetic variation in microRNA precursors could influence the processing and expression of microRNAs, which could affect the prognosis of lung cancer. We aimed to investigate the impact of single nucleotide polymorphisms (SNPs) of pri-let-7 on the prognosis of non-small cell lung cancer (NSCLC).
METHOD
A total of 761 patients with surgically resected NSCLC were included. Four SNPs (pri-let-7a-2 rs1143770 and rs629367, pri-let-7a-1 rs10739971, and pri-let-7f-2 rs17276588) were genotyped using sequenom mass spectrometry-based genotyping assay. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier method and Cox proportional hazards model.
RESULTS
Of the 4 SNPs evaluated, the rs1143770C>T was found to be significantly associated with OS and DFS. The rs1143770 CT or TT genotype exhibited a significantly better OS and DFS compared with the rs1143770 CC genotype (adjusted hazard ratio for OS=0.67, confidence interval, 0.49-0.91, P=0.01 and adjusted hazard ratio for DFS=0.74, confidence interval, 0.58-0.95, P=0.02).
CONCLUSION
This observation indicates that pri-let-7a-2 rs1143770C>T may have a prognostic impact on surgically resected NSCLC.
背景
有证据表明，微小RNA的let-7可能是肺癌的一个预后因素。微小RNA前体的基因变异可能会影响微小RNA的加工和表达，进而可能影响肺癌的预后。我们旨在研究pri-let-7的单核苷酸多态性（SNP）对非小细胞肺癌（NSCLC）预后的影响。
方法
共纳入761例接受手术切除的NSCLC患者。使用基于Sequenom质谱的基因分型检测方法对4个SNP（pri-let-7a-2 rs1143770和rs629367、pri-let-7a-1 rs10739971以及pri-let-7f-2 rs17276588）进行基因分型。采用Kaplan-Meier法和Cox比例风险模型评估总生存期（OS）和无病生存期（DFS）。
结果
在所评估的4个SNP中，发现rs1143770C>T与OS和DFS显著相关。与rs1143770 CC基因型相比，rs1143770 CT或TT基因型的OS和DFS显著更好（OS的调整风险比=0.67，置信区间为0.49-0.91，P=0.01；DFS的调整风险比=0.74，置信区间为0.58-0.95，P=0.02）。
结论
该观察结果表明，pri-let-7a-2 rs1143770C>T可能对手术切除的NSCLC预后有影响。
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