Division of Clinical Research, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Division of Pathology, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
World J Gastroenterol. 2019 Feb 28;25(8):1012-1023. doi: 10.3748/wjg.v25.i8.1012.
The lethal-7 () family members and their targets are involved in the development and progression of tumors. -related polymorphisms have been reported to be associated with tumorigenesis and prognosis. In gastric cancer, however, the related studies are limited.
To investigate the role of -related microRNA polymorphisms in the tumorigenesis and prognosis of gastric cancer in a Chinese population.
A total of 898 gastric cancer patients and 992 tumor-free controls were recruited into this study from 2008 to 2013. Gastric cancer patients were followed periodically. Ten single nucleotide polymorphisms (SNPs) in the gene region or their target mRNAs were genotyped using the MassARRAY system and their associations with the risk for or overall survival of gastric cancer were analyzed.
All the ten SNPs were in Hardy-Weinberg equilibrium. The C allele of the rs3811463 polymorphism in the 3'-untranslated region (UTR) of was associated with a lower risk of gastric cancer [odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.61-0.88, = 0.001] after adjustment for age and status. Seven hundred and thirty-five gastric cancer patients who had undergone radical tumorectomy were included in the survival analysis and their 5-year survival rate was 53.9% (95%CI: 50.1%-57.6%). The rs10889677 in the 3'-UTR of was corresponded to the prognosis of gastric cancer in a dose-response manner, in which the death risk increased by 25% [hazard ratio (HR) = 1.25, 95%CI: 1.04-1.45, = 0.011] with each increase in the number of C alleles after controlling for other potential clinicopathological parameters.
The -related polymorphism rs3811463 in is associated with the susceptibility to gastric cancer and the -related polymorphism rs10889677 in is associated with the prognosis of gastric cancer.
致死-7（lethal-7，L7）家族成员及其靶基因参与肿瘤的发生和发展。L7 相关多态性与肿瘤发生和预后有关。然而，在胃癌中，相关研究有限。
在中国人群中研究 L7 相关 microRNA 多态性在胃癌发生和预后中的作用。
本研究共纳入 2008 年至 2013 年间 898 例胃癌患者和 992 例无肿瘤对照。定期随访胃癌患者。采用 MassARRAY 系统对基因区域或其靶 mRNA 的 10 个单核苷酸多态性（SNP）进行基因分型，并分析其与胃癌发病风险或总生存的关系。
所有 10 个 SNP 均处于哈迪-温伯格平衡状态。在 L7 的 3'-非翻译区（UTR）中 rs3811463 多态性的 C 等位基因与胃癌发病风险降低相关（优势比[OR] = 0.74，95%置信区间[CI]：0.61-0.88，= 0.001），校正年龄和肿瘤分期后。735 例接受根治性肿瘤切除术的胃癌患者纳入生存分析，其 5 年生存率为 53.9%（95%CI：50.1%-57.6%）。L7 的 3'-UTR 中的 rs10889677 与胃癌的预后呈剂量反应关系，在控制其他潜在临床病理参数后，随着 C 等位基因数的增加，死亡风险增加 25%（风险比[HR] = 1.25，95%CI：1.04-1.45，= 0.011）。
L7 相关多态性 rs3811463 与胃癌易感性有关，L7 相关多态性 rs10889677 与胃癌预后有关。
