Maha Athip, Rukachaisirikul Vatcharin, Saithong Saowanit, Phongpaichit Souwalak, Poonsuwan Wimarak, Sakayaroj Jariya, Saparpakorn Patchreenart, Hannongbua Supa
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Phytochemistry. 2016 Feb;122:223-229. doi: 10.1016/j.phytochem.2015.11.009. Epub 2015 Nov 27.
Investigation of the fungus Phoma herbarum PSU-H256 isolated from a leaf of Hevea brasiliensis resulted in the isolation of eight terezine derivatives (E-L) together with four known compounds. Their structures were established by analysis of spectroscopic evidence. For terezines E and H, their structures were confirmed by single-crystal X-ray diffraction crystallography. In addition, the absolute configuration at C-7 in terezine E was established by Mosher's method. Terezines K and L were tested for antibacterial, antimalarial, antimycobacterial and cytotoxic activities, but were inactive.
对从巴西橡胶树叶中分离出的草本茎点霉PSU - H256进行研究，结果分离出了8种特瑞嗪衍生物（E - L）以及4种已知化合物。通过光谱证据分析确定了它们的结构。对于特瑞嗪E和H，通过单晶X射线衍射晶体学确定了它们的结构。此外，通过莫舍尔方法确定了特瑞嗪E中C - 7位的绝对构型。对特瑞嗪K和L进行了抗菌、抗疟、抗分枝杆菌和细胞毒性活性测试，但它们没有活性。
