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Eutyscoparols A-G,来源于内生真菌 Eutypella scoparia SCBG-8 的聚酮衍生物。

Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8.

机构信息

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, People's Republic of China.

出版信息

Fitoterapia. 2020 Oct;146:104681. doi: 10.1016/j.fitote.2020.104681. Epub 2020 Jul 3.

Abstract

The chemical investigation on Eutypella scoparia SCBG-8, an endophytic fungus isolated from the leaves of Leptospermum brachyandrum, has resulted in the isolation of six new phenolic compounds eutyscoparols A-F (1-6) and one new natural product eutyscoparol G (7). The structures and absolute configurations of compounds 1-7 were determined by extensive chemical and spectroscopic analyses such as single crystal X-ray diffractions. Moreover, all compounds were evaluated for their antibacterial and cytotoxic activities in vitro.

摘要

从桃金娘科白千层属植物变叶白千层叶片内生真菌短序白千层中分离得到的真菌短序白千层内生真菌进行化学成分研究,从中分离得到 6 个新的酚类化合物 eutyscoparols A-F(1-6)和 1 个新天然产物 eutyscoparol G(7)。通过单晶 X 射线衍射等广泛的化学和光谱分析确定了化合物 1-7 的结构和绝对构型。此外,还评估了所有化合物的体外抗菌和细胞毒性活性。

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