Takemoto Jody K, Remsberg Connie M, Davies Neal M
Department of Pharmaceutical Sciences, Ben and Maytee Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, Texas. Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, Washington.
J Pharm Pharm Sci. 2015;18(4):713-27. doi: 10.18433/j33w4c.
Delineate the selected pharmacodynamics of a naturally occurring stilbene 3'-Hydroxypterostilbene.
Characterize for the first time the pharmacodynamics bioactivity in several in-vitro assays with relevant roles in heart disease, inflammation, cancer, and diabetes etiology and pathophysiology.
3'-Hydroxypterostilbene was studied in in-vitro assays to identify possible bioactivity.
3'-Hydroxypterostilbene demonstrated anti-oxidant, anti-inflammatory, cytotoxic, anti-adipogenic, histone deacetylase, and sirtuin-1 inhibitory activity.
The importance of understanding individual stilbene pharmacologic activities were delineated. Small changes in chemical structure of stilbene compounds result in significant pharmacodynamic differences. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
描述天然存在的芪类化合物3'-羟基蝶芪的选定药效学。
首次在几种体外试验中表征其药效学生物活性，这些试验在心脏病、炎症、癌症和糖尿病的病因及病理生理学中具有相关作用。
在体外试验中研究3'-羟基蝶芪以确定可能的生物活性。
3'-羟基蝶芪表现出抗氧化、抗炎、细胞毒性、抗脂肪生成、组蛋白脱乙酰酶和沉默调节蛋白-1抑制活性。
阐述了了解单个芪类化合物药理活性的重要性。芪类化合物化学结构的微小变化会导致显著的药效学差异。本文接受发表后审查。注册读者（见“致读者”）可通过点击本期目录页面上的摘要进行评论。
