Department of Food Science, Rutgers University, New Brunswick, NJ, USA.
Department of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan.
J Food Drug Anal. 2017 Jan;25(1):134-147. doi: 10.1016/j.jfda.2016.07.004. Epub 2016 Sep 22.
Stilbenes are a class of polyphenolic compounds, naturally found in a wide variety of dietary sources such as grapes, berries, peanuts, red wine, and some medicinal plants. There are several well-known stilbenes including trans-resveratrol, pterostilbene, and 3'-hydroxypterostilbene. The core chemical structure of stilbene compounds is 1,2-diphenylethylene. Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activities. Moreover, accumulating in vitro and in vivo studies have reported that stilbene compounds act as inducers of multiple cell-death pathways such as apoptosis, cell cycle arrest, and autophagy for chemopreventive and chemotherapeutic agents in several types of cancer cells. The aim of this review is to highlight recent molecular findings and biological actions of trans-resveratrol, pterostilbene, and 3'-hydroxypterostilbene.
二苯乙烯类化合物是一类多酚类化合物，天然存在于各种饮食来源中，如葡萄、浆果、花生、红酒和一些药用植物。有几种著名的二苯乙烯类化合物，包括反式白藜芦醇、紫檀芪和 3'-羟基紫檀芪。二苯乙烯类化合物的核心化学结构是 1,2-二苯基乙烯。最近，由于二苯乙烯类化合物具有广泛的健康有益作用，如抗炎、抗癌、抗糖尿病和抗血脂作用，因此引起了广泛的关注和兴趣。此外，越来越多的体外和体内研究报告称，二苯乙烯类化合物作为多种细胞死亡途径的诱导剂，如凋亡、细胞周期停滞和自噬，可作为几种类型癌细胞的化学预防和化学治疗剂。本综述的目的是强调反式白藜芦醇、紫檀芪和 3'-羟基紫檀芪的最新分子发现和生物学作用。
