Yamaguchi Eduardo Tsuyoshi, Siaulys Mônica Maria, Torres Marcelo Luis Abramides
Hospital Universitário da Universidade de São Paulo (HU-USP), São Paulo, SP, Brasil.
Hospital e Maternidade Santa Joana, São Paulo, SP, Brasil.
Rev Bras Anestesiol. 2016 Jul-Aug;66(4):402-7. doi: 10.1016/j.bjan.2014.11.005. Epub 2015 Nov 26.
Oxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10 IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.
缩宫素是预防和治疗产后子宫收缩乏力的首选子宫收缩剂。然而，对于剖宫产术中使用的最佳剂量和速度尚无共识。使用高剂量推注（例如10国际单位缩宫素）可导致对患者有害的心血管变化，尤其是在低血容量或心脏储备不足的情况下。此外，长时间使用高剂量缩宫素可能导致子宫肌层中缩宫素受体脱敏，从而导致临床无效。
