Raz E, Michaeli J, Brezis M, Popovtzer M M, Gazitt Y, Shouval D
Department of Medicine, Mount Scopus, Hadassah University Hospital, Jerusalem, Israel.
Am J Nephrol. 1989;9(2):162-6. doi: 10.1159/000167957.
A case of hypocomplementemic membranoproliferative glomerulonephritis was studied during remission of nephrosis induced by high doses of corticosteroids. Hepatitis B surface antigen (HBsAg) and immune complexes were detected in serum and glomeruli. Anti-hepatitis-B surface antibody, undetectable in serum by conventional radioimmunoassays was identified in circulating immune complexes (CIC). On two occasions, improvement in renal function coincided paradoxically with an extreme increase in serum HBsAg levels as well as with marked elevation of CIC. We suggest that, as previously observed in animal models of glomerulonephritis, extreme antigen excess may inhibit glomerular deposition of immune complexes.
对一例补体减少性膜增生性肾小球肾炎患者在大剂量皮质类固醇诱导的肾病缓解期进行了研究。在血清和肾小球中检测到乙型肝炎表面抗原（HBsAg）和免疫复合物。在循环免疫复合物（CIC）中鉴定出常规放射免疫分析在血清中检测不到的抗乙型肝炎表面抗体。有两次，肾功能的改善与血清HBsAg水平的极度升高以及CIC的显著升高同时出现。我们认为，正如先前在肾小球肾炎动物模型中观察到的那样，抗原极度过量可能会抑制免疫复合物在肾小球的沉积。
