Ras E, Michaeli J, Rosenmann E, Popovtzer M M, Polliack A, Shouval D
Department of Medicine, Mount Scopus, Jerusalem, Israel.
Leuk Lymphoma. 1993 Jun;10(3):241-4. doi: 10.3109/10428199309145890.
The development of B-cell immunoblastic lymphoma in a 51 year old patient with hepatitis B virus related immune complex nephritis is described. The lymphoma was diagnosed eleven months after the administration of high dose corticosteroids which resulted in a striking increase in the HBsAg serum titer up to 1:1,000,000. This unusual association raises a number of interesting questions regarding the link between immune complex nephritis and immunoblastic lymphoma. The significance of corticosteroid therapy leading to excessive HBsAg secretion and the role played by this intense antigenic stimulation in the pathogenesis of lymphoma in this particular patient are also discussed.
本文描述了一名51岁患有乙型肝炎病毒相关免疫复合物性肾炎的患者发生B细胞免疫母细胞性淋巴瘤的病例。该淋巴瘤在给予大剂量皮质类固醇治疗11个月后被诊断出来，这导致血清HBsAg滴度显著升高至1:1,000,000。这种不寻常的关联引发了一些关于免疫复合物性肾炎与免疫母细胞性淋巴瘤之间联系的有趣问题。还讨论了皮质类固醇治疗导致HBsAg分泌过多的意义以及这种强烈抗原刺激在该特定患者淋巴瘤发病机制中所起的作用。
