Reid Brian J, Culotti Joseph G, Nash Robert S, Pringle John R
Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109 Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195.
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1X5, Canada.
Mol Biol Cell. 2015 Dec 1;26(24):4307-12. doi: 10.1091/mbc.E14-10-1484.
In the early 1970s, studies in Leland Hartwell's laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.
20世纪70年代初，华盛顿大学利兰·哈特韦尔实验室的研究开启了对真核细胞周期的遗传分析，并奠定了通向我们如今对这一核心重要过程理解的道路。这篇45周年回顾文章审视了该项目成形的各个步骤、项目开展时的氛围以及对当代可能具有的启示。它还对最初的35个CDC基因及其人类同源基因进行了最新介绍。
