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本文引用的文献

1
High FOXM1 expression was associated with bladder carcinogenesis.高叉头框M1（FOXM1）表达与膀胱癌发生相关。
Tumour Biol. 2013 Apr;34(2):1131-8. doi: 10.1007/s13277-013-0654-x. Epub 2013 Jan 17.
2
The molecular pathogenesis of osteosarcoma: a review.骨肉瘤的分子发病机制：综述
Sarcoma. 2011;2011:959248. doi: 10.1155/2011/959248. Epub 2011 Apr 13.
3
Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy.中东结直肠癌的全基因组表达分析揭示 FOXM1 是癌症治疗的新靶点。
Am J Pathol. 2011 Feb;178(2):537-47. doi: 10.1016/j.ajpath.2010.10.020.
4
Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis.转录因子 FoxM1 内皮细胞特异性缺失可增加尿烷诱导的肺癌发生。
Cancer Res. 2011 Jan 1;71(1):40-50. doi: 10.1158/0008-5472.CAN-10-2004.
5
Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1.Raf/MEK/MAPK信号传导刺激FOXM1的核转位和反式激活活性。
Methods Mol Biol. 2010;647:113-23. doi: 10.1007/978-1-60761-738-9_6.
6
The epidemiology of osteosarcoma.骨肉瘤的流行病学
Cancer Treat Res. 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1.
7
FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance.FOXM1 是 ERalpha 的转录靶标，在乳腺癌内分泌敏感性和耐药性中起关键作用。
Oncogene. 2010 May 20;29(20):2983-95. doi: 10.1038/onc.2010.47. Epub 2010 Mar 8.
8
FOXM1 confers acquired cisplatin resistance in breast cancer cells.FOXM1 赋予乳腺癌细胞获得性顺铂耐药性。
Mol Cancer Res. 2010 Jan;8(1):24-34. doi: 10.1158/1541-7786.MCR-09-0432. Epub 2010 Jan 12.
9
Prognostic factors in the survival of patients diagnosed with primary non-metastatic osteosarcoma with a poor response to neoadjuvant chemotherapy.原发性非转移性骨肉瘤患者对新辅助化疗反应不良的生存预后因素。
Clinics (Sao Paulo). 2009;64(12):1177-86. doi: 10.1590/S1807-59322009001200007.
10
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.刺猬靶基因：异常刺猬信号激活诱导的致癌机制。
Curr Mol Med. 2009 Sep;9(7):873-86. doi: 10.2174/156652409789105570.

叉头框蛋白M1可预测人类骨肉瘤的预后。

Forkhead box protein M1 predicts outcome in human osteosarcoma.

作者信息

Fan Chong-Lang, Jiang Jian, Liu Hu-Cheng, Yang Dong

机构信息

Department of Orthopedics, The First Affiliated Hospital of Nanchang University Nanchang 330006, China.

Department of Orthopedics, The First Affiliated Hospital of Nanchang University Nanchang 330006, China ; Department of Orthopedics, The People's Hospital of Shangrao Shangrao 334000, China.

出版信息

Int J Clin Exp Med. 2015 Sep 15;8(9):15563-8. eCollection 2015.

PMID:26629049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4658938/
Abstract

PURPOSE

In the present study, we examined both FOXM1 mRNA and protein expression by Real-time quantitative PCR (qRT-PCR) and Western blot and investigate the expression of the human FOXM1 by Immunohistochemistry (IHC), and identify their potential roles in prognosis for patients with osteosarcoma.

METHODS

FOXM1 mRNA and protein expression levels were detected by RT-PCR and Western blot assays, respectively. Then, IHC was performed to analyze the association of FOXM1 expression in 83 osteosarcoma tissues with clinicopathological factors and survival of patients.

RESULTS

The expression levels of FOXM1 mRNA were found to be significantly increased in osteosarcoma tissues compared to noncancerous bone tissues (P = 0.0313). Simultaneously, western blot analysis showed that the protein level of FOXM1 in osteosarcoma tissues was significantly higher than that in noncancerous bone tissues. Kaplan-Meier analysis with the log-rank test indicated that high FOXM1 expression had a significant impact on overall survival (P = 0.0001).

CONCLUSIONS

Our data showed that FoxM1 was upregulated in osteosarcoma tissues, and high expression of FoxM1 was correlated with a poor prognosis of patients with osteosarcoma. FoxM1 may function as a valuable prognostic biomarker for osteosarcoma.

摘要

目的

在本研究中，我们通过实时定量聚合酶链反应（qRT-PCR）和蛋白质免疫印迹法检测了叉头框蛋白M1（FOXM1）的mRNA和蛋白质表达，并通过免疫组织化学（IHC）研究了人FOXM1的表达，以确定它们在骨肉瘤患者预后中的潜在作用。

方法

分别通过逆转录聚合酶链反应（RT-PCR）和蛋白质免疫印迹法检测FOXM1的mRNA和蛋白质表达水平。然后，进行免疫组织化学分析83例骨肉瘤组织中FOXM1表达与临床病理因素及患者生存情况的相关性。

结果

与非癌性骨组织相比，骨肉瘤组织中FOXM1的mRNA表达水平显著升高（P = 0.0313）。同时，蛋白质免疫印迹分析表明，骨肉瘤组织中FOXM1的蛋白质水平显著高于非癌性骨组织。采用对数秩检验的Kaplan-Meier分析表明，高FOXM1表达对总生存期有显著影响（P = 0.0001）。

结论

我们的数据表明，FoxM1在骨肉瘤组织中上调，且FoxM1的高表达与骨肉瘤患者的不良预后相关。FoxM1可能作为骨肉瘤一个有价值的预后生物标志物。