Kong Bin, Lv Zhi-Dong, Chen Li, Shen Ruo-Wu, Jin Li-Ying, Yang Zhao-Chuan
Department of Breast Surgery, The Affiliated Hospital of Qingdao University Qingdao 266003, P. R. China.
Institute of Basic Sciences, Shandong Academy of Medical Sciences Jinan 250000, P. R. China.
Int J Clin Exp Med. 2015 Sep 15;8(9):15808-14. eCollection 2015.
Several studies have investigated the associations between XRCC2 R188H polymorphism and the susceptibility to breast cancer, but the results have been inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed.
PubMed and China National Knowledge Infrastructure (CNKI) searches were carried out for relevant studies published before March 2015. Meta-analysis was performed with the Stata, version 11.0.
A total of 17 case-control studies, including 17,986 cases and 17,436 controls, were selected. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the homozygous model, dominant model, and recessive model. When all the studies were pooled into the meta-analysis, there was no evidence showing a significant association between XRCC2 R188H polymorphism and breast cancer risk (for homozygous model, OR=0.84, 95% CI=0.62-1.14; for dominant model: OR=0.76, 95% CI=0.53-1.09; and for recessive model: OR=1.04, 95% CI=0.98-1.10). In the subgroup analysis by ethnicity, no significant association was found between the polymorphism and breast cancer risk.
In conclusion, this meta-analysis indicates that the XRCC2 R188H polymorphism is not a risk factor for developing of breast cancer.
多项研究探讨了XRCC2基因R188H多态性与乳腺癌易感性之间的关联，但结果尚无定论。为了更精确地估计两者关系，我们进行了一项荟萃分析。
检索了PubMed和中国知网（CNKI），查找2015年3月之前发表的相关研究。使用Stata 11.0软件进行荟萃分析。
共纳入17项病例对照研究，包括17986例病例和17436例对照。采用粗比值比（OR）及95%置信区间（CI）评估纯合子模型、显性模型和隐性模型中的关联强度。当将所有研究纳入荟萃分析时，没有证据表明XRCC2基因R188H多态性与乳腺癌风险之间存在显著关联（纯合子模型：OR = 0.84，95% CI = 0.62 - 1.14；显性模型：OR = 0.76，95% CI = 0.53 - 1.09；隐性模型：OR = 1.04，95% CI = 0.98 - 1.10）。在按种族进行的亚组分析中，未发现该多态性与乳腺癌风险之间存在显著关联。
总之，该荟萃分析表明XRCC2基因R188H多态性不是乳腺癌发生的危险因素。
