线粒体与过氧化物酶体之间的相互作用
Crosstalk between mitochondria and peroxisomes.
作者信息
Demarquoy Jean, Le Borgne Françoise
机构信息
Jean Demarquoy, Françoise Le Borgne, Université de Bourgogne, UFR SVTE, 21000 Dijon, France.
出版信息
World J Biol Chem. 2015 Nov 26;6(4):301-9. doi: 10.4331/wjbc.v6.i4.301.
Abstract
Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles in cell metabolism, especially in terms of fatty acid metabolism, reactive oxygen species (ROS) production, and ROS scavenging, and it is now clear that they metabolically interact with each other. These two organelles share some properties, such as great plasticity and high potency to adapt their form and number according to cell requirements. Their functions are connected, and any alteration in the function of mitochondria may induce changes in peroxisomal physiology. The objective of this paper was to highlight the interconnection and the crosstalk existing between mitochondria and peroxisomes. Special emphasis was placed on the best known connections between these organelles: origin, structure, and metabolic interconnections.
摘要
线粒体和过氧化物酶体是普遍存在的小型细胞器。它们在细胞代谢中都发挥着重要作用，尤其是在脂肪酸代谢、活性氧（ROS）生成和ROS清除方面，并且现在很清楚它们在代谢上相互作用。这两种细胞器具有一些共同特性，例如具有很大的可塑性以及根据细胞需求调整其形态和数量的高效能力。它们的功能相互关联，线粒体功能的任何改变都可能诱导致过氧化物酶体生理学的变化。本文的目的是强调线粒体和过氧化物酶体之间存在的相互联系和相互作用。特别强调了这些细胞器之间最广为人知的联系：起源、结构和代谢相互联系。
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