Delmez J A
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Mo.
Blood Purif. 1989;7(2-3):167-80. doi: 10.1159/000169588.
The purpose of this article is to review the basic pathophysiological events leading to renal osteodystrophy and how continuous ambulatory peritoneal dialysis may alter these processes. This form of therapy has significant effects on mineral homeostasis and may, under some circumstances, alter vitamin D and parathyroid hormone metabolism. Some short-term studies suggest that there may be an improvement in bone histology during treatment. Although much remains to be learned about renal osteodystrophy and continuous ambulatory peritoneal dialysis, enough information is currently available to allow implementation of a rational plan of therapy that should optimize mineral metabolism.
本文旨在综述导致肾性骨营养不良的基本病理生理过程，以及持续性非卧床腹膜透析如何改变这些过程。这种治疗方式对矿物质稳态有显著影响，在某些情况下可能会改变维生素D和甲状旁腺激素的代谢。一些短期研究表明，治疗期间骨组织学可能会有所改善。尽管关于肾性骨营养不良和持续性非卧床腹膜透析仍有许多有待了解的地方，但目前已有足够的信息来实施合理的治疗方案，以优化矿物质代谢。
