Freundlich M, Zilleruelo G, Abitbol C, Hwang K H, Bourgoignie J J, Strauss J
Nephron. 1985;41(3):267-72. doi: 10.1159/000183595.
Peritoneal fluxes of minerals and bone-modulating hormones and their impact on corresponding serum levels and bone mineralization in 7 children on continuous ambulatory peritoneal dialysis (CAPD) were studied. Most mass transfer studies revealed modest losses of calcium into peritoneal effluents. Peritoneal losses of phosphorus and magnesium, although substantial, were not sufficient to normalize hyperphosphatemia and hypermagnesemia in most patients. Parathormone and vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) were readily detectable in peritoneal effluents. Improved bone mineral content, by sequential densitometries, was associated with amelioration of hyperparathyroidism. These data suggest that CAPD in children induces an overall improvement of disturbed mineral metabolism; nevertheless, peritoneal losses of calcium and vitamin D metabolites must be considered and replenished appropriately.
研究了7名接受持续性非卧床腹膜透析（CAPD）的儿童的矿物质和骨调节激素的腹膜通量及其对相应血清水平和骨矿化的影响。大多数物质转移研究表明，钙向腹膜流出液中的损失较小。磷和镁的腹膜损失虽然很大，但在大多数患者中不足以使高磷血症和高镁血症恢复正常。甲状旁腺激素和维生素D代谢产物（25-羟基维生素D和1,25-二羟基维生素D）在腹膜流出液中很容易检测到。通过连续骨密度测量，骨矿物质含量的改善与甲状旁腺功能亢进的改善相关。这些数据表明，儿童CAPD可使紊乱的矿物质代谢总体得到改善；然而，必须考虑并适当补充钙和维生素D代谢产物的腹膜损失。
