Tekin Burak, Kempf Werner, Seckin Dilek, Ergun Tulin, Yucelten Deniz, Demirkesen Cuyan
*Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey; †Kempf und Pfaltz, Histologische Diagnostik, Zürich, Switzerland; and ‡Department of Pathology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Am J Dermatopathol. 2016 Feb;38(2):138-43. doi: 10.1097/DAD.0000000000000406.
Mycosis fungoides (MF) simulates a variety of dermatologic disorders histopathologically and clinically, well deserving the designation of a great mimicker. Interstitial MF is a rare, but well-recognized histopathological variant resembling the interstitial form of granuloma annulare or the inflammatory phase of morphea. From a clinical standpoint, MF can have a wide array of manifestations, including an anecdotal presentation with lesions clinically suggestive of lichen sclerosus (LS). We herein report a 25-year-old man with a history of patch-stage MF who later developed widespread LS-like lesions histopathologically consistent with interstitial MF. In some biopsies, additional features resembling LS were discerned. We think that our case might represent a unique variant of interstitial MF presenting with LS-like lesions. The diagnostic challenge arising from this uncommon presentation is discussed together with review of the literature.
蕈样肉芽肿（MF）在组织病理学和临床上可模拟多种皮肤病，堪称典型的模仿者。间质型MF是一种罕见但已得到充分认识的组织病理学变体，类似于环状肉芽肿的间质型或硬斑病的炎症期。从临床角度来看，MF可有多种表现，包括有临床上提示硬化性苔藓（LS）病变的罕见表现。我们在此报告一名25岁男性，有斑块期MF病史，后来出现了广泛的类似LS的病变，组织病理学检查与间质型MF一致。在一些活检中，还发现了其他类似LS的特征。我们认为我们的病例可能代表了一种伴有类似LS病变的间质型MF的独特变体。结合文献复习，讨论了这种罕见表现所带来的诊断挑战。
