Battaglia F C
Department of Pediatrics and OB/GYN, University of Colorado School of Medicine, Denver.
Biol Neonate. 1989;55(6):347-54. doi: 10.1159/000242938.
This paper presents a review of fetal and placental metabolism, particularly as it relates to carbohydrate and amino acid metabolism. The strengths of simultaneous application of the Fick principle methodology for the determination of net substrate fluxes with tracer methodology for estimating rates of fetal and placental utilization of compounds is discussed and illustrated. The interconversion of nutrients, both within the fetus and in the placenta, is reviewed with particular emphasis on potential cycling of nutrients between the placenta and fetal liver. Recent work defining the changes in fetal and placental metabolism at mid gestation is also discussed. This work is used as an example illustrating the importance of defining a wide gestational age window for study of ontogenetic changes in fetal metabolism. Finally, recent clinical studies utilizing cordocentesis or periumbilical blood sampling for evaluating the biochemical environment of the human fetus at mid gestation are reviewed and compared to data obtained under chronic steady-state conditions in fetal sheep.
本文综述了胎儿和胎盘的代谢，尤其是与碳水化合物和氨基酸代谢相关的内容。讨论并举例说明了同时应用菲克原理方法测定净底物通量和示踪方法估算胎儿及胎盘对化合物利用速率的优势。回顾了胎儿和胎盘内营养物质的相互转化，特别强调了胎盘与胎儿肝脏之间营养物质潜在的循环。还讨论了近期关于妊娠中期胎儿和胎盘代谢变化的研究工作。这项工作被用作一个例子，说明为研究胎儿代谢的个体发生变化而定义一个较宽的孕周窗口的重要性。最后，对近期利用脐静脉穿刺术或脐周血采样评估妊娠中期人类胎儿生化环境的临床研究进行了综述，并与在慢性稳态条件下从胎羊获得的数据进行了比较。
