Battaglia F C
Fed Proc. 1986 Sep;45(10):2508-12.
Uteroplacental tissues have been shown to have a high rate of metabolism under in vivo steady-state conditions. Fully two-thirds of the glucose and one-half of the oxygen consumed by the uterus are utilized by these tissues rather than by the fetus. Its high metabolic rate must be borne in mind in any analysis of tracer kinetics, which prohibits the exclusion of these tissues and the use of a two-compartment model for analysis of carbohydrate and amino acid metabolism. Current techniques permit determination of utilization rates of nutrients in all three compartments (fetal, uteroplacental, and maternal) with considerable precision. Using tracer amino acids one can determine rates of protein synthesis and protein breakdown as well as rates of amino acid oxidation. These techniques should prove useful in investigating the role of various trophic factors in fetal life and in assessing the impact of changes in placental function or maternal nutritional state on fetal growth and metabolism.
在体内稳态条件下，子宫胎盘组织已被证明具有很高的代谢率。子宫消耗的葡萄糖中足足三分之二以及氧气的一半是由这些组织而非胎儿利用的。在任何示踪动力学分析中都必须牢记其高代谢率，这使得不能排除这些组织，也不能使用两室模型来分析碳水化合物和氨基酸代谢。目前的技术能够相当精确地测定所有三个部分（胎儿、子宫胎盘和母体）中营养物质的利用率。使用示踪氨基酸可以确定蛋白质合成和蛋白质分解的速率以及氨基酸氧化的速率。这些技术在研究各种营养因子在胎儿生命中的作用以及评估胎盘功能或母体营养状态的变化对胎儿生长和代谢的影响方面应会证明是有用的。
