Guo Hui-Min, Liu Mei, Xiang Yu-Tao, Zhao Jing, Ungvari Gabor S, Correll Christoph U, Ng Chee H, Chiu Helen F K, Duan Zhong-Ping
Artificial Liver Treatment and Training Center, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Faculty of Health Sciences, University of Macau, Macao, SAR, China.
Perspect Psychiatr Care. 2017 Jan;53(1):67-72. doi: 10.1111/ppc.12138. Epub 2015 Dec 3.
To determine the frequency and socio-demographic/clinical correlates of insomnia in patients with chronic hepatitis B, hepatitis B virus (HBV)-related liver failure, and cirrhosis.
Up to 120 patients with HBV-related diseases and 40 matched healthy controls were recruited. Depressive and anxiety symptoms, early, middle, and late insomnia were measured.
The frequency of ≥1 type of insomnia was 64.2% in patients and 35.0% in controls; frequencies of early, middle, and late insomnia in patients were 39.2%, 42.5%, and 48.3%, respectively, compared to 22.5%, 10.0%, and 25.0% in controls. Urban residency was independently associated with less insomnia of any type, accounting for 22.6% of the variance.
A considerable proportion of patients with HBV-related diseases suffer from insomnia that warrants more attention in clinical practice.
确定慢性乙型肝炎、乙型肝炎病毒（HBV）相关肝衰竭和肝硬化患者失眠的发生率以及社会人口统计学/临床相关因素。
招募了多达120例HBV相关疾病患者和40名匹配的健康对照者。测量了抑郁和焦虑症状、早、中、晚期失眠情况。
患者中≥1种失眠类型的发生率为64.2%，对照组为35.0%；患者早期、中期和晚期失眠的发生率分别为39.2%、42.5%和48.3%，而对照组分别为22.5%、10.0%和25.0%。城市居住与任何类型的失眠较少独立相关，占变异的22.6%。
相当一部分HBV相关疾病患者存在失眠问题，在临床实践中值得更多关注。
