纽芬兰与拉布拉多省阿根廷地区癌症发病率调查：一项生态学研究。
An investigation of cancer rates in the Argentia region, Newfoundland and Labrador: an ecological study.
作者信息
Duke Pauline, Godwin Marshall, Peach Mandy, Fortier Jacqueline, Bornstein Stephen, Buehler Sharon, McCrate Farah, Pike Andrea, Wang Peizhong Peter, Cullen Richard M
机构信息
Primary Healthcare Research Unit, Memorial University, St. John's, NL, Canada A1B 3V6 ; Discipline of Family Medicine, Memorial University, St. John's, NL, Canada A1B 3V6.
Primary Healthcare Research Unit, Memorial University, St. John's, NL, Canada A1B 3V6.
出版信息
J Environ Public Health. 2015;2015:421562. doi: 10.1155/2015/421562. Epub 2015 Nov 8.
BACKGROUND
The Argentia region of Newfoundland and Labrador, Canada, was home to a US naval base during a 40-year period between the 1940s and the 1990s. Activities on the base resulted in contamination of the soil and groundwater in the region with chemicals such as heavy metals and dioxins, and residents have expressed concern about higher rates of cancer in their community. This study investigated the rate of cancer diagnosis that is disproportionately high in the Argentia region.
METHODS
Cases of cancer diagnosed between 1985 and 2011 were obtained for the Argentia region, two comparison communities, and the province of Newfoundland and Labrador. Crude and age-standardized incidence rates of cancer diagnosis were calculated and compared. The crude incidence rate was adjusted for differences in age demographics using census data, and age-standardized incidence rates were compared.
RESULTS
Although the Argentia region had a higher crude rate of cancer diagnosis, the age-standardized incidence rate did not differ significantly from the comparison communities or the provincial average. Argentia has an aging population, which may have influenced the perception of increased cancer diagnosis in the community.
CONCLUSIONS
We did not detect an increased burden of cancer in the Argentia region.
背景
在20世纪40年代至90年代的40年期间，加拿大纽芬兰和拉布拉多省的阿真舍地区曾是一个美国海军基地。基地的活动导致该地区的土壤和地下水被重金属和二恶英等化学物质污染，当地居民对社区中较高的癌症发病率表示担忧。本研究调查了阿真舍地区异常高的癌症诊断率。
方法
获取了阿真舍地区、两个对照社区以及纽芬兰和拉布拉多省在1985年至2011年间诊断出的癌症病例。计算并比较了癌症诊断的粗发病率和年龄标准化发病率。使用人口普查数据对粗发病率进行了年龄人口统计学差异调整，并比较了年龄标准化发病率。
结果
尽管阿真舍地区的癌症诊断粗发病率较高，但其年龄标准化发病率与对照社区或全省平均水平并无显著差异。阿真舍地区人口老龄化，这可能影响了社区对癌症诊断增加的认知。
结论
我们未发现阿真舍地区的癌症负担增加。
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