Luo X-H, Li G-R, Li H-Y
Department of Geriatrics, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Railway Vocational and Technical College of Zhengzhou, Zhengzhou, China.
Genet Mol Res. 2015 Nov 26;14(4):15133-9. doi: 10.4238/2015.November.25.1.
Previous case-control studies on the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension have produced contrasting results. In this study, we aimed to further evaluate the relationship between the CYP4F2 gene rs2108622 polymorphism and hypertension. We selected four case-control studies related to the CYP4F2 gene rs2108622 polymorphism and hypertension by searching PubMed, EMBase, the Chinese Biomedical Literature Database, and the Wanfang database. We utilized the Cochran Q-test and the I2 index to measure the heterogeneity across studies. To merge the odds ratio (OR) and the 95% confidence interval (95%CI), we utilized the fixed and random-effect models during the analyses. The present study included 1878 patients with hypertension and 1512 healthy control subjects. By meta-analysis, we did not find any association of the CYP4F2 gene rs2108622 polymorphism with hypertension in either genotype or allele distribution [AA+AG vs GG: OR = 1.18, 95%CI (0.91-1.54), P = 0.21; GG+AG vs AA: OR = 0.91, 95%CI (0.80-1.05), P = 0.20; A allele vs G allele: OR = 1.04, 95%CI (0.93-1.16), P = 0.53]. We concluded that the CYP4F2 gene rs2108622 polymorphism was not associated with hypertension.
先前关于CYP4F2基因rs2108622多态性与高血压之间关系的病例对照研究得出了相互矛盾的结果。在本研究中，我们旨在进一步评估CYP4F2基因rs2108622多态性与高血压之间的关系。我们通过检索PubMed、EMBase、中国生物医学文献数据库和万方数据库，选取了四项与CYP4F2基因rs2108622多态性和高血压相关的病例对照研究。我们使用Cochran Q检验和I2指数来衡量各研究间的异质性。为合并比值比（OR）和95%置信区间（95%CI），我们在分析过程中使用了固定效应模型和随机效应模型。本研究纳入了1878例高血压患者和1512例健康对照者。通过荟萃分析，我们发现在基因型或等位基因分布方面，CYP4F2基因rs2108622多态性与高血压均无关联[AA + AG vs GG：OR = 1.18，95%CI（0.91 - 1.54），P = 0.21；GG + AG vs AA：OR = 0.91，95%CI（0.80 - 1.05），P = 0.20；A等位基因vs G等位基因：OR = 1.04，95%CI（0.93 - 1.16），P = 0.53]。我们得出结论，CYP4F2基因rs2108622多态性与高血压无关。
