Mendonça Marcelo D, Caetano André, Viana-Baptista Miguel
1 Neurology Department, Hospital Egas Moniz - Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
2 CEDOC, Nova Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.
Cephalalgia. 2016 Oct;36(11):1077-1081. doi: 10.1177/0333102415620285. Epub 2016 Jul 21.
Aims Migraine and depression have a strong association. We aimed to determine whether this relationship was particularly evident in migraineurs with allodynia. Methods A cross-sectional study was carried out of 98 consecutive patients with episodic migraine presenting for their first evaluation in an outpatient clinic. The participants completed a demographic questionnaire, the Allodynia Symptom Checklist and the Hospital Anxiety and Depression Scale (HADS). Results Among the migraineurs, 75 (77%) reported allodynia. Allodynia was associated with higher median HADS-Anxiety (9 vs. 6, p = 0.038) and HADS-Depression (6 vs. 4, p = 0.014) scores. In a multiple regression model, the HADS-Depression scores were independently associated with allodynia (odds ratio 1.236, 95% confidence interval 1.046-1.461). An increased severity of allodynia correlated with higher depression scores ( r = 0.224; p = 0.027). Conclusion Anxious and depressive symptoms are more common in migraineurs with allodynia than in those without allodynia. Further studies are necessary to clarify the relationship between depressive symptoms and allodynia, as well as its therapeutic implications in migraine.
目的 偏头痛与抑郁症之间存在密切关联。我们旨在确定这种关系在患有痛觉过敏的偏头痛患者中是否尤为明显。方法 对98例连续在门诊进行首次评估的发作性偏头痛患者进行了一项横断面研究。参与者完成了一份人口统计学调查问卷、痛觉过敏症状清单和医院焦虑抑郁量表（HADS）。结果 在偏头痛患者中，75例（77%）报告有痛觉过敏。痛觉过敏与更高的HADS焦虑中位数（9对6，p = 0.038）和HADS抑郁中位数（6对4，p = 0.014）得分相关。在多元回归模型中，HADS抑郁得分与痛觉过敏独立相关（比值比1.236，95%置信区间1.046 - 1.461）。痛觉过敏严重程度增加与更高的抑郁得分相关（r = 0.224；p = 0.027）。结论 与无痛觉过敏的偏头痛患者相比，有痛觉过敏的偏头痛患者中焦虑和抑郁症状更为常见。需要进一步研究以阐明抑郁症状与痛觉过敏之间的关系及其在偏头痛治疗中的意义。
