Nishimura Naomichi, Tanabe Hiroki, Yamamoto Tatsuro
a Faculty of Health and Welfare Science, Department of Nutritional Sciences , Nayoro City University , Nayoro , Japan.
b College of Agriculture, Academic Institute, Shizuoka University , Shizuoka , Japan.
Biosci Biotechnol Biochem. 2016;80(3):554-63. doi: 10.1080/09168451.2015.1104237. Epub 2015 Dec 3.
Colonic hydrogen (H2) protects against inflammation-induced oxidative stress. We examined the effect of a new highly branched α-glucan, isomaltodextrin (IMD), on colonic H2 production in rats. Rats were fed a 16.7% IMD, 8.8% indigestible dextrin (ID), or 10.4% high amylose cornstarch diet (Expt. 1), were fed diets containing 3.3-16.7% IMD (Expt. 2), or were fed diets containing 16.7% IMD or 5.2% fructooligosaccharide (FOS) (Expt. 3), for 14 days. Compared with the control group, feeding IMD or other α-glucans dose dependently and significantly increased H2 excretion and portal H2 concentration. The ability of IMD to increase H2 production was not inferior to that of FOS. The cecal Firmicutes/Bacteroidetes ratio in the IMD group was 5-14% of that in the control group. The cecal abundance of bifidobacteria was significantly greater in the IMD group than in the control group. Taken together, IMD, as well as other α-glucans, significantly increased colonic H2 production in a dose-dependent manner.
结肠氢气（H2）可抵御炎症诱导的氧化应激。我们研究了一种新型高度分支的α-葡聚糖异麦芽糊精（IMD）对大鼠结肠H2产生的影响。在实验1中，给大鼠喂食含16.7%IMD、8.8%难消化糊精（ID）或10.4%高直链玉米淀粉的日粮；在实验2中，给大鼠喂食含3.3 - 16.7%IMD的日粮；在实验3中，给大鼠喂食含16.7%IMD或5.2%低聚果糖（FOS）的日粮，持续14天。与对照组相比，喂食IMD或其他α-葡聚糖可剂量依赖性且显著增加H2排泄及门静脉H2浓度。IMD增加H2产生的能力不低于FOS。IMD组盲肠厚壁菌门/拟杆菌门的比例为对照组的5 - 14%。IMD组盲肠中双歧杆菌的丰度显著高于对照组。综上所述，IMD以及其他α-葡聚糖可剂量依赖性地显著增加结肠H2的产生。
