内皮素对大鼠肾功能的影响。

Effect of endothelin on renal function in rats.

作者信息

López-Farré A, Montañés I, Millás I, López-Novoa J M

机构信息

Medical Research Institute, Fundación Jiménez Díaz-Consejo Superior de Investigaciones Científicas, Madrid, Spain.

出版信息

Eur J Pharmacol. 1989 Apr 12;163(1):187-9. doi: 10.1016/0014-2999(89)90417-2.

DOI:10.1016/0014-2999(89)90417-2

PMID:2663528

Abstract

The effect of synthetic porcine endothelin on glomerular filtration rate, renal plasma flow and electrolyte excretion was studied in rats. Endothelin, 1 nmol/kg body weight given as a bolus, induced a transient decrease in glomerular filtration rate (72%) and in renal plasma flow (76%) as well as in sodium excretion, accompanied by a sustained increase in renal vascular resistance. This dose had no sustained effect on mean arterial pressure. It is concluded that endothelin induces a marked decrease in glomerular filtration rate and renal perfusion. This peptide could play a role in the alterations in renal function observed after renal injury.

摘要

研究了合成猪内皮素对大鼠肾小球滤过率、肾血浆流量和电解质排泄的影响。以1 nmol/kg体重的剂量推注内皮素，可引起肾小球滤过率（下降72%）、肾血浆流量（下降76%）以及钠排泄的短暂降低，并伴有肾血管阻力的持续增加。该剂量对平均动脉压无持续影响。结论是内皮素可导致肾小球滤过率和肾灌注显著降低。这种肽可能在肾损伤后观察到的肾功能改变中起作用。