Gooriah Rubesh, Buture Alina, Ahmed Fayyaz
Department of Neurology, Hull Royal Infirmary, Kingston upon Hull, UK.
Ther Clin Risk Manag. 2015 Nov 9;11:1687-96. doi: 10.2147/TCRM.S94193. eCollection 2015.
Cluster headache (CH), one of the most painful syndromes known to man, is managed with acute and preventive medications. The brief duration and severity of the attacks command the use of rapid-acting pain relievers. Inhalation of oxygen and subcutaneous sumatriptan are the two most effective acute therapeutic options for sufferers of CH. Several preventive medications are available, the most effective of which is verapamil. However, most of these agents are not backed by strong clinical evidence. In some patients, these options can be ineffective, especially in those who develop chronic CH. Surgical procedures for the chronic refractory form of the disorder should then be contemplated, the most promising of which is hypothalamic deep brain stimulation. We hereby review the pathogenesis of CH and the evidence behind the treatment options for this debilitating condition.
丛集性头痛（CH）是人类已知的最疼痛的综合征之一，通过急性和预防性药物进行治疗。发作的短暂持续时间和严重程度决定了需要使用速效止痛药。吸氧和皮下注射舒马曲坦是CH患者两种最有效的急性治疗选择。有几种预防性药物可供使用，其中最有效的是维拉帕米。然而，这些药物大多缺乏强有力的临床证据支持。在一些患者中，这些选择可能无效，尤其是那些发展为慢性CH的患者。对于这种疾病的慢性难治性形式，应考虑手术治疗，其中最有前景的是下丘脑深部脑刺激术。我们在此回顾CH的发病机制以及针对这种使人衰弱的疾病的治疗选择背后的证据。
